Costal cartilage transplantation for treatment of growth plate injury in a rabbit model

Otsuki, Dai; Yoshida, Kiyoshi; Kobayashi, Masato; Hamano, Daisuke; Higuchi, Chikahisa; Yoshikawa, Hideki

doi:10.1302/1863-2548-11-160209

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…The medial half of the growth plate of the tibia 1mm burr was used to remove the medial half of the proximal tibial growth plate 50% IGF-I-loaded PLGA scaffolds √ √ √ Rabbits [21] Distal femur Unknown 3.5 mm drill bit Unknown Hydrogels √ √ Rabbits [22] Proximal tibia…”

Section: √ √mentioning

confidence: 99%

Evaluating reduced bone bridge formation through a modified rat epiphyseal plate injury model

Wang

et al. 2023

Preprint

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Approximately, one-third of all pediatric fractures involve the metaphyseal region, causing damage to the growth plate (also known as the epiphyseal plate), leading to unwanted bone repair tissue through the growth plate, known as a bone bridge (or bony bar). In some cases, the bony bar affects the longitudinal growth of long bones, resulting in limb shortening and angulation deformity and affecting children's physical and mental health. In clinical practice, the primary methods used to prevent the formation of bone bridges are fat interposition, anatomic reduction, and appropriate fixation. Once a bone bridge is formed, resection is the main treatment, but its formation usually takes one to two months, and limb shortening and angulation deformity usually take longer or even years. Therefore, prevention has become the focus of clinical and basic research. In this study, a modified rat central growth plate drilling injury model of the proximal tibia was established based on the original research using a silicone gel membrane to seal the holes. The modified model was provided for the study of reducing bone bridge formation. The hole's volume was evaluated using intraoperative and postoperative imaging examinations to determine the maximum volume of drug administration. Prevention of bone bridge formation was achieved using noninvasive medication; its effect was verified using various methods, providing a new in vivo animal experiment for the prevention and treatment of bone bridge formation after epiphyseal plate injury to guide clinical practice.

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Section: √ √mentioning

confidence: 99%

Evaluating reduced bone bridge formation through a modified rat epiphyseal plate injury model

Wang

et al. 2023

Preprint

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“…[4,5] At present, the methods of cartilage repair mainly include microfracture, cartilage transplantation, and chondrocyte transplantation. [6][7][8][9] Unfortunately, the effect of these methods is not satisfactory, and the vast majority of patients face the outcome of late joint replacement. [10] Therefore, it is an urgent clinical need to find an effective treatment strategy for cartilage injury.…”

Section: Introductionmentioning

confidence: 99%

Chondroitin Sulfate Improves Mechanical Properties of Gelatin Hydrogel for Cartilage Regeneration in Rats

Lei,

Tong,

Zhai

et al. 2023

Advanced Biology

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Cartilage injury is a common disease in daily life. Especially in aging populations, the incidence of osteoarthritis is increasing. However, due to the poor regeneration ability of cartilage, most cartilage injuries cannot be effectively repaired. Even cartilage tissue engineering still faces many problems such as complex composition and poor integration of scaffolds and host tissues. In this study, chondroitin sulfate, one of the main components of extracellular matrix (ECM), is chosen as the main natural component of the material, which can protect cartilage in a variety of ways. Moreover, the results show that the addition of chondroitin sulfate improves the mechanical properties of gelatin methacrylate (GelMA) hydrogel, making it able to effectively bear mechanical loads in vivo. Further, chondroitin sulfate is modified to obtain the oxidized chondroitin sulfate (OCS) containing aldehyde groups via sodium periodate. This special group improves the interface integration and adhesion ability of the hydrogel to host cartilage tissue through schiff base reactions. In summary, GelMA/OCS hydrogel is a promising candidate for cartilage regeneration with good biocompatibility, mechanical properties, tissue integration ability, and excellent cartilage repair ability.

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“…As a result, the costal cartilage graft is considered a safe and effective choice for use in growth plate cartilage regeneration. 41 Lee et al extracted cells from the resting zone of 6-week-old rabbit costal growth plates cartilage. They used the 3D chondrocyte pellet culture technique to produce tissue-engineered grafts with cytological characteristics of typical growth plates.…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

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The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

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Costal cartilage transplantation for treatment of growth plate injury in a rabbit model

Cited by 7 publications

References 26 publications

Evaluating reduced bone bridge formation through a modified rat epiphyseal plate injury model

Evaluating reduced bone bridge formation through a modified rat epiphyseal plate injury model

Chondroitin Sulfate Improves Mechanical Properties of Gelatin Hydrogel for Cartilage Regeneration in Rats

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

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