Costosternal Syndrome

Wolf, E

doi:10.1001/archinte.1976.03630020043010

Cited by 41 publications

(4 citation statements)

References 17 publications

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“…The etiology is mysterious, however, its diagnostic profile has been crystallizing over the last half century. The incidence of Tietze's Syndrome is not well studied, but in 1976, a study of 320 patients with precordial chest pain yielded almost a 10% incidence of Costosternal Syndrome, including Tietze's Syndrome [3]. It is most commonly diagnosed in 20 to 50 year old patients, but can strike young pediatric and elderly patients [6,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…A 2008 study recommends MRI and a 2010 review recommended bone scintigraphy and ultrasound as screening tests [11,15]. There have been some histological inquiries, but the studies have thus far deemed histology to be unrevealing or unimportant [3,6,12].…”

Section: Discussionmentioning

confidence: 99%

“…While frequently discussed and included in differential diagnoses, they are often inappropriately consolidated and misunderstood. Tietze's Syndrome (which has also been referred to as Costosternal Syndrome, Anterior Chest Wall Syndrome, Parasternal Chondrodynia, Thoracochondalgia, Chondropathia Tuberose, and Costochondral Junction Syndrome) is an uncommon musculoskeletal pathology, which was first described in 1921 by Alexander Tietze [2][3][4]. The National Institutes of Health lists it as a rare disease, indicating the limited available information about the syndrome as well as its possible rarity [5].…”

Section: Introductionmentioning

confidence: 99%

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Tietze’s Syndrome in the emergency department: A rare etiology of atraumatic chest pain

Grodin¹,

Farina²

2013

CRCM

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Tietze's Syndrome is an uncommon disorder that presents with painful, tender, non-suppurative swelling of the anterior chest wall. We report a case of a female patient who presented to the emergency department with a chief complaint of atraumatic chest pain and swelling of the anterior chest wall. After a thorough history and physical examination, as well as basic laboratory tests and chest radiography, she was diagnosed with Tietze's Syndrome. The expedient accurate diagnosis of Tietze's Syndrome is important for the physical and emotional well-being of a patient, and avoids overlooking more dangerous pathologies. Tietze's Syndrome needs to be considered in the differential diagnosis of a patient presenting with spontaneous swelling of the anterior chest.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tietze’s Syndrome in the emergency department: A rare etiology of atraumatic chest pain

Grodin¹,

Farina²

2013

CRCM

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“…Derivatization of the carboxylic acid group of NSAIDs into esters or amide prodrugs has been proven to be an effective method that lessens their gastrointestinal ulcerogenic adverse effects [9][10] . Mefenamic acid, which is a very potent antiinflammatory drug used in several inflammatory diseases such as mild to moderate pain, arthritis, dysmenorrhea, etc., is also associated with various side effects like an upset stomach, gastric irritation, and erosion of the gastroduodenal mucosa 11 . Based on the literature available, it has been concluded that co-administration of mefenamic acid with paracetamol or the other NSAIDs may reduce the possibility of NSAIDs induced gastrointestinal ulcerogenicity.…”

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confidence: 99%

Untitled

2023

IJPSR

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Inflammation and pain have all been successfully treated using nonsteroidal anti-inflammatory drugs. Today's nonsteroidal anti-inflammatory drugs (NSAIDs) are typically taken with restriction due to the gastric intolerance they create. The prodrug approach is quite effective in reducing the side effects caused by NSAIDs. Many nonsteroidal anti-inflammatory drug molecules have been modified in several ways so that they can be less hazardous to the stomach. Using the mutual prodrug concept, the side effects can be minimized by covalently bonding the NSAIDs to the second pharmacologically active carrier. The goal of the current study is to use the coupling approach to create mutual ester prodrugs of NSAIDs (MS and MP) in order to overcome the troubles, they cause, like gastrointestinal toxicity, ulcerogenic side effects, etc. The prodrugs were made by using a better reagent, EDAC 1-Ethyl-3-(3-Dimethylaminopropyl) carbodiimide hydrochloride, because it outperformed DCC (N, N′-Dicyclohexylcarbodiimide) as a coupling agent. The physiochemical properties were determined, and the structures of the synthesized prodrugs were confirmed and analyzed by UV, FT-IR, 1 HNMR, 13 CNMR Spectroscopy and Mass spectrometry. INTRODUCTION:The clinical importance of NSAIDs is enormous, but there's a robust risk that they might have negative effects on the abdomen. The ability of NSAIDs to restrict the activity of the enzyme cyclooxygenase (COX) involved in prostaglandin H 2 (PGH 2 ) production is correlated with their pharmacological effectiveness 1, 2 . It is generally known that COX has two isoforms, COX-I and COX-II, which are controlled in various ways. In the GIT, COX-I is expressed constitutively in the stomach to provide cytoprotection, and COX-II plays a major role in the biosynthesis of prostaglandin, which is expressed in inflammatory cell 3 .

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