Costs of COPD in Sweden According to Disease Severity

Jansson, Sven-Arne; Andersson, Fredrik; Borg, Sixten; Ericsson, Åsa; Jonsson, E. Niclas; Lundbäck, Bo

doi:10.1378/chest.122.6.1994

Cited by 158 publications

(163 citation statements)

References 21 publications

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“…Disease severity, most commonly diagnosed by clinical FEV 1 measurements but also self-reported, has previously been reported as having strong links with resource use and costs. (3,23) Hence, the results were very much expected. What stands out is the fact that two additional variables contribute even further and thus we arrive at an even better prediction of patient costs.…”

Section: Discussionmentioning

confidence: 69%

“…The analysis was based on a data set consisting of 179 subjects, a representative cohort of subjects with COPD in Sweden. (3,11) Poor lung function (measured by FEV 1 ) significantly increased all six cost types. Disease severity, most commonly diagnosed by clinical FEV 1 measurements but also self-reported, has previously been reported as having strong links with resource use and costs.…”

Section: Discussionmentioning

confidence: 97%

“…The study sample and methods have been described in detail previously. (3,11) Of 261 selected subjects, 212 individuals did agree to be interviewed about resource utilisation on four occasions in the course of a year. A structured telephone interview, using a specially designed and pilot-tested questionnaire, was conducted by one of the authors (SAJ).…”

Section: Study Samplementioning

confidence: 99%

“…(1) COPD is also a costly disease, generating considerable health-care costs as well as indirect costs in terms of lost productivity from days off work, early retirement and death caused by disease. (2)(3)(4)(5)(6) Earlier research has identified several risk factors that affect the costs of COPD. For example, Crocket et al showed a dependency between co-morbidity and length of stay in hospital.…”

Section: Introductionmentioning

confidence: 99%

“…(6,8) In addition, poor lung function affects health-care utilisation. (3,(9)(10)(11) However, few studies have been carried out which are detailed multivariate analysis of COPD costs. (12) As COPD is a complex disease with multiple facets it is essential to take into account the effect on costs from a number of potentially influencing factors and not to focus on one individual background factor at a time, as has been done in previous research.…”

Section: Introductionmentioning

confidence: 99%

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Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

et al. 2008

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Methods: A cohort of 179 subjects with COPD was interviewed over the telephone on four occasions about their annual use of COPD-related resources. The data set and the explanatory variables were analysed by means of multivariate regression techniques for six different types of cost: societal (or total), direct (health care) and indirect (productivity), and three subcomponents of direct costs -hospitalisation, outpatient, and medication.Results: Poor lung function, dyspnoea and asthma were independently associated with higher costs. Poor lung function (severity of COPD) significantly increased all six examined cost types. Dyspnoea (breathing problems) also did this, though to a varying extent. The presence of reported asthma increased total, direct, outpatient and medication costs. Conclusions:Poor lung function and, to a lesser extent, extent of dyspnoea and concomitant asthma, were all strongly associated with higher COPD-related costs. Strong efforts should be made to prevent the progression of COPD and its symptoms.Word count: 178

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 97%

Section: Study Samplementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

et al. 2008

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Economic Burden of COPD

Au¹,

Sullivan²

2007

Chronic Obstructive Pulmonary Disease

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Three‐dimensional accurate detection of lung emphysema in rats using ultra‐short and zero echo time MRI

et al. 2015

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Emphysema is a life-threatening pathology that causes irreversible destruction of alveolar walls. In vivo imaging techniques play a fundamental role in the early non-invasive pre-clinical and clinical detection and longitudinal follow-up of this pathology. In the present study, we aimed to evaluate the feasibility of using high resolution radial three-dimensional (3D) zero echo time (ZTE) and 3D ultra-short echo time (UTE) MRI to accurately detect lung pathomorphological changes in a rodent model of emphysema.Porcine pancreas elastase (PPE) was intratracheally administered to the rats to produce the emphysematous changes. 3D ZTE MRI, low and high definition 3D UTE MRI and micro-computed tomography images were acquired 4 weeks after the PPE challenge. Signal-to-noise ratios (SNRs) were measured in PPE-treated and control rats. T2* values were computed from low definition 3D UTE MRI. Histomorphometric measurements were made after euthanizing the animals. Both ZTE and UTE MR images showed a significant decrease in the SNR measured in PPE-treated lungs compared with controls, due to the pathomorphological changes taking place in the challenged lungs. A significant decrease in T2* values in PPE-challenged animals compared with controls was measured using UTE MRI. Histomorphometric measurements showed a significant increase in the mean linear intercept in PPE-treated lungs. UTE yielded significantly higher SNR compared with ZTE (14% and 30% higher in PPE-treated and non-PPE-treated lungs, respectively).This study showed that optimized 3D radial UTE and ZTE MRI can provide lung images of excellent quality, with high isotropic spatial resolution (400 µm) and SNR in parenchymal tissue (>25) and negligible motion artifacts in freely breathing animals. These techniques were shown to be useful non-invasive instruments to accurately and reliably detect the pathomorphological alterations taking place in emphysematous lungs, without incurring the risks of cumulative radiation exposure typical of micro-computed tomography.

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Costs of COPD in Sweden According to Disease Severity

Cited by 158 publications

References 21 publications

Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

Economic Burden of COPD

Three‐dimensional accurate detection of lung emphysema in rats using ultra‐short and zero echo time MRI

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