Costs of illness in chronic inflammatory demyelinating polyneuropathy in Germany

Mengel, David; Fraune, Linda; Sommer, Norbert; Stettner, Mark; Reese, Jens Peter; Dams, Judith; Glynn, Robert J.; Balzer‐Geldsetzer, Monika; Dodel, Richard; Tackenberg, Björn

doi:10.1002/mus.26315

Cited by 24 publications

(46 citation statements)

References 20 publications

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“…Depression has not been well characterized in CIDP but has been reported to occur in 9% of Dutch patients 30 ; 12% of German patients 31 ; and 31% of patients assessed in Serbia, Bosnia and Herzegovina, and Montenegro 32 . Our findings provide insight into the frequency of depression in patients from the United States, and also further characterize depression as a function of active disease.…”

Section: Discussionmentioning

confidence: 71%

“…Improved sleep hygiene with exposure to timed light therapy and cognitive-behavioral therapy for insomnia (CBT-I) also may be beneficial, as these interventions have been shown to improve both poor sleep quality and fatigue in autoimmune conditions. [26][27][28][29] Depression has not been well characterized in CIDP but has been reported to occur in 9% of Dutch patients 30 ; 12% of German patients 31 ; and 31% of patients assessed in Serbia, Bosnia and Herzegovina, and Montenegro. 32 Our findings provide insight into the frequency of depression in patients from the United States, and also further characterize depression as a function of active disease.…”

Section: Predictors Of Fatigue In Patients With Cidpmentioning

confidence: 99%

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Fatigue in chronic inflammatory demyelinating polyneuropathy

2020

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Introduction: In this study we aimed to better understand fatigue in chronic inflammatory demyelinating polyneuropathy (CIDP) as it relates to disease activity status. Methods: Patients with probable or definite CIDP were stratified into active CIDP or CIDP in remission. Assessments of fatigue, physical impairment, disability, sleepiness, sleep quality, and depression were collected. Results: Of the 85 patients included in the study, 46 (54%) had active disease, whereas 39 (46%) were in remission. Fatigue was substantial in both groups, but was more severe in the active group. Use of sedating medications was a major contributor to fatigue. Sleep quality was poor in both groups, whereas depression more commonly affected those with active CIDP. Inflammatory Neuropathy Cause and Treatment disability, poor sleep quality, and higher level of depression had the greatest effect on fatigue severity. Discussion: Fatigue is common in CIDP regardless of the disease activity state. Minimizing sedating medications, improving sleep quality, and managing depression may improve CIDP-associated fatigue.

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Section: Discussionmentioning

confidence: 71%

Section: Predictors Of Fatigue In Patients With Cidpmentioning

confidence: 99%

Fatigue in chronic inflammatory demyelinating polyneuropathy

2020

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“…Nevertheless, it is notable that, in both studies, patients with atypical CIDP were less responsive to intravenous immunoglobulin (IVIg), and this points to a different underlying pathophysiology. 3 12 Separately, recent studies also highlight the economic burden of CIDP: the annual costs for CIDP are calculated at around €45 000 in Germany, 13 above £22 000 (£49 000 for patients on IVIg) in the UK 14 and more than $50 000 in the USA, mostly due to repeated or maintenance IVIg treatment. 15…”

Section: Epidemiology and Economic Burdenmentioning

confidence: 99%

Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment

Lehmann

Burke

Kuwabara

2019

J Neurol Neurosurg Psychiatry

183

110

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Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy typically characterised by symmetrical involvement, and proximal as well as distal muscle weakness (typical CIDP). However, there are several ‘atypical’ subtypes, such as multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome) and ‘distal acquired demyelinating symmetric neuropathy’, possibly having different immunopathogenesis and treatment responses. In the absence of diagnostic and pathogenetic biomarkers, diagnosis and treatment may be difficult, but recent progress has been made in the application of neuroimaging tools demonstrating nerve hypertrophy and in identifying subgroups of patients who harbour antibodies against nodal proteins such as neurofascin and contactin-1. Despite its relative rarity, CIDP represents a significant economic burden, mostly due to costly treatment with immunoglobulin. Recent studies have demonstrated the efficacy of subcutaneous as well as intravenous immunoglobulin as maintenance therapy, and newer immunomodulating drugs can be used in refractory cases. This review provides an overview focusing on advances over the past several years.

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“…Mood disorders are associated with different variants of neuropathy from diabetic, inflammatory, and chemotherapy-associated neuropathy [26,27,28]. The prevalence of depression is also greater in diabetics who have neuropathy [29,30].…”

Section: Discussionmentioning

confidence: 99%

Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster

Thawani

Wang

Shao

et al. 2019

IJERPH

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We examined whether time to onset of paresthesia was associated with indicators of severity of World Trade Center (WTC) exposure. We analyzed data from 3411 patients from the Bellevue Hospital—WTC Environmental Health Center. Paresthesia was defined as present if the symptom occurred in the lower extremities with frequency “often” or “almost continuous.” We plotted hazard functions and used the log-rank test to compare time to onset of paresthesia between different exposure groups. We also used Cox regression analysis to examine risk factors for time-to-paresthesia after 9/11/2001 and calculate hazard ratios adjusted for potential confounders. We found significantly elevated hazard ratios for paresthesia for (a) working in a job that required cleaning of WTC dust in the workplace; and (b) being heavily exposed to WTC dust on September 11, 2001, after adjusting for age, race/ethnicity, depression, anxiety, post-traumatic stress disorder, and body mass index. These observational data are consistent with the hypothesis that exposure to WTC dust or some other aspect of cleaning WTC dust in the workplace, is associated with neuropathy and paresthesia. Further neurological evaluations of this and other WTC-exposed populations is warranted.

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Costs of illness in chronic inflammatory demyelinating polyneuropathy in Germany

Abstract: CIDP is associated with high societal costs, mainly resulting from the cost of IVIg treatment. Muscle Nerve 58: 681-687, 2018.

Cited by 24 publications

References 20 publications

Fatigue in chronic inflammatory demyelinating polyneuropathy

Fatigue in chronic inflammatory demyelinating polyneuropathy

Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment

Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster

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