Costs of perennial allergic rhinitis and allergic asthma increase with severity and poor disease control

Belhassen, Manon; Demoly, Pascal; Bloch-Morot, E.; Pouvourville, Gérard de; Ginoux, M.; Chartier, A.; Laforest, Laurent; Serup-Hansen, Niels; Toussi, Massoud; Ganse, Éric Van

doi:10.1111/all.13098

Cited by 43 publications

(24 citation statements)

References 37 publications

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“…In 2 recent studies for allergic rhinitis and allergic asthma, the direct and indirect costs have clearly increased with severity and poor control of the condition [28, 29]. However, the cost effect of multimorbidity has not been analyzed in any detail.…”

Section: Discussionmentioning

confidence: 99%

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey

Jantunen

Haahtela

Salimäki³

et al. 2019

Int Arch Allergy Immunol

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Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs. Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Altogether, 956 patients (5–75 years) who purchased asthma or allergy drugs with prescription participated in 351 pharmacies. Results: Of the participants, 78% reported physician-diagnosed asthma, 57% allergic rhinitis, 24% atopic eczema, 21% food allergy, 20% allergic conjunctivitis, 8% anaphylaxis, and 8% COPD. One-third of the patients had at least three conditions, and multimorbidity was common across all age groups. Disease severity increased with the number of coexisting conditions, and asthma severity also with age. Patients with asthma alone used on average 3.8 drugs with the annual costs of EUR 661. This increased to 4.9 drugs and EUR 847 in asthmatics with multimorbidity. For all participants, costs of drugs and healthcare services together during the preceding year were on average EUR 1,214, of which 56% were drug costs. The costs doubled to EUR 2,714 in 65 subjects (7%) who had both asthma and COPD. Conclusions: In asthma and allergy, multimorbidity and polypharmacy are major concerns. Disease severity, drug use, and costs increased with multimorbid conditions. To reduce the burden, allergy management should be better integrated and more comprehensive.

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Section: Discussionmentioning

confidence: 99%

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey

Jantunen

Haahtela

Salimäki³

et al. 2019

Int Arch Allergy Immunol

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“…In a recent study, Belhassen et al [85] analyzed the healthcare data of 52,621 patients in France between 18 and 65 years in 2010, and found a prevalence of allergic rhinitis of 6.8% in this age band. In total, 26.2% of these patients were also diagnosed with allergic asthma.…”

Section: Direct Healthcare Costsmentioning

confidence: 99%

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Dierick

Molen

Blok

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

229

157

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Introduction: Asthma, allergic rhinitis, atopic dermatitis, and food allergy affect approximately 20% of the global population. Few studies describe the burden of the totality of these diseases and only a handful studies provide a comprehensive overview of the socioeconomic impact of these diseases. Areas covered: For this narrative review, we searched Pubmed using selected keywords and inspected relevant references using a snowballing process. We provide an overview of the socioeconomic burden of allergic diseases (in particular, asthma, allergic rhinitis, atopic dermatitis, and food allergy). The focus of this review is on their epidemiology (incidence, prevalence), burden (disability-adjusted life years, quality of life), and direct and indirect costs (absenteeism and presenteeism). We have put special emphasis on differences between countries. Expert commentary: Both the prevalence and the burden of allergic diseases are considerable with prevalence varying between 1% and 20%. We identified a plethora of studies on asthma, but studies were generally difficult to compare due to the heterogeneity in measures used. There were only few studies on the burden of food allergy; therefore, more studies on this allergy are required. For future studies, we recommend standardizing epidemiologic, socioeconomic impact, and quality of life measures of allergic diseases.

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“…2 Importantly, air pollution is currently one of the leading causes of premature death in the world. 3,4 Allergic rhinitis (AR) and asthma share many pathophysiological links 5,6 and are among the commonest respiratory conditions, 7,8 with their increasing prevalence mirroring the rise in Westernized lifestyle worldwide. 9 Because the airways represent one of the major boundaries of the body, environmental exposures (collectively termed "the exposome") 10 greatly affect the homeostasis of the respiratory mucosae.…”

Section: Introductionmentioning

confidence: 99%

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

Eguiluz‐Gracia

Mathioudakis

Bartel

et al. 2020

Allergy

308

193

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Air pollution and climate change have a significant impact on human health and well‐being and contribute to the onset and aggravation of allergic rhinitis and asthma among other chronic respiratory diseases. In Westernized countries, households have experienced a process of increasing insulation and individuals tend to spend most of their time indoors. These sequelae implicate a high exposure to indoor allergens (house dust mites, pets, molds, etc), tobacco smoke, and other pollutants, which have an impact on respiratory health. Outdoor air pollution derived from traffic and other human activities not only has a direct negative effect on human health but also enhances the allergenicity of some plants and contributes to global warming. Climate change modifies the availability and distribution of plant‐ and fungal‐derived allergens and increases the frequency of extreme climate events. This review summarizes the effects of indoor air pollution, outdoor air pollution, and subsequent climate change on asthma and allergic rhinitis in children and adults and addresses the policy adjustments and lifestyle changes required to mitigate their deleterious effects.

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Costs of perennial allergic rhinitis and allergic asthma increase with severity and poor disease control

Abstract: This study linking diagnoses from EHRs to claims data collected valid information on PAR management, with or without concomitant AA, and on related costs. There was a clear increase in costs with severity of PAR and control of AA.

Cited by 43 publications

References 37 publications

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

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