Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress

Abstract

Diabetes mellitus (DM) is a common metabolic disorder worldwide and has gradually become an epidemic in recent years. Elevated blood glucose levels typically cause a series of tissue injury-related events during diabetes, resulting in diabetic complications such as diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic foot disease and retinopathy. Among these diabetic complications, DCM is considered a risk factor of heart failure, known to be associated with disability and mortality in patients with diabetes. 1 DCM persistently presents as diastolic dysfunction during the early stage, progressing to systolic dysfunction in the advanced phase.

Inhibiting AGS Cancer Cell Proliferation through the Combined Application of Aucklandiae Radix and Hyperthermia: Investigating the Roles of Heat Shock Proteins and Reactive Oxygen Species

“…In our study, costunolide and dehydrocostus lactone, the two primary components of AR, drew significant attention. Both compounds are known for their broad-spectrum biological activities such as anti-inflammatory, anti-microbial, anti-ulcer, and anti-cancer features [51][52][53][54]. Notably, the mechanisms underlying their anti-cancer effects include inducing ROS and promoting apoptosis, which reflects our current findings [55][56][57].…”

Lysophosphatidylcholine trigger myocardial injury in diabetic cardiomyopathy via the TLR4/ZNF480/AP-1/NF-kB pathway

“…This condition may, in turn, be a fundamental factor in the enhanced activity of LCAT within the circulatory system, potentially resulting in the elevated levels of LPC. Higher levels of LPC have been demonstrated to induce islet dysfunction [ 8 , 9 ], resulting in insulin resistance, a central pathogenic feature of T2DM [ 39 ]. The present indicated the increased levels of LPC in T2DM patients, accompanied by degeneration and necrosis of pancreatic islets, as well as the elevated serum insulin levels in T2DM mice.…”

“…The pathogenesis of DC is multifactorial, involving hyperlipidemia, lipotoxicity, hyperglycemia, and inflammation [ 5 ]. Chronic hyperglycemia has been identified as a key risk factor for the onset and progression of DC [ [6] , [7] , [8] , [9] ]. Nevertheless, the molecular mechanisms underlying lipid metabolism disorder-induced myocardial injury remain elusive.…”