Costus root aqueous extract modulates rat liver toxicity, DNA damage, injury, proliferation alterations induced by plant growth regulator Ethephon

Effectiveness of curcumin nanoparticles in rat liver fibrosis caused by thioacetamide

“…The level of cellular damage was strongly related to the elevation in these enzymes (ALT, AST, ALP), which suggests enhanced permeability, liver damage, and hepatocyte necrosis. 11,45 Elevation of ALT, AST may reflect increased liver injury due to the enhanced generation of ROS by hepatic microsomes, where it reduces di-oxygen to oxygen-derived radicals and H 2 O 2 . 46 Our findings concur with those of Al-Medhtiy et al and Bardi et al, who found that TAA induced liver toxicity due to the elevation in liver enzymes (ALT, AST, ALP) and depletion in albumin and total proteins.…”

“…A significant rise in ALT, AST, ALP, LDH, and a significant depletion in albumin and total proteins levels were detected in rats treated with TAA when compared to control, curcumin and curcumin nanoparticles. The level of cellular damage was strongly related to the elevation in these enzymes (ALT, AST, ALP), which suggests enhanced permeability, liver damage, and hepatocyte necrosis 11,45 . Elevation of ALT, AST may reflect increased liver injury due to the enhanced generation of ROS by hepatic microsomes, where it reduces di‐oxygen to oxygen‐derived radicals and H 2 O 2 46 .…”

“…10 Correlative and elective pharmaceutical use has significantly increased in recent years. [11][12][13][14] Several medicinal plant extracts and their secondary metabolites have strong antioxidant activity by lowering reactive oxygen species (ROS) generation, making them a key characteristic of therapeutic plant liver toxicity. [15][16][17][18][19][20] Originally derived from the Curcuma longa plant, curcumin is a polyphenol that has a number of advantageous qualities, including antioxidant, antibacterial, inflammatory, and anticancer.…”

“…Correlative and elective pharmaceutical use has significantly increased in recent years 11–14 . Several medicinal plant extracts and their secondary metabolites have strong antioxidant activity by lowering reactive oxygen species (ROS) generation, making them a key characteristic of therapeutic plant liver toxicity 15–20 …”

التأثیر الوقائی لجذور القسط الهندی على اضطرابات الکبد المستحث برابع کلورید الکربون فی الفئران

“…Because most drugs go through the first-pass metabolism in the liver, it is the primary target of toxicity for several chemicals. As a result, it becomes a crucial organ for researching the effects of various drugs injected into the body (Tousson et al, 2020). Storage, filtration, excretory, and metabolic processes are all performed by the liver.…”