1989
DOI: 10.1902/jop.1989.60.4.176
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Cotinine in Saliva and Gingival Crevicular Fluid of Smokers With Periodontal Disease

Abstract: A study was undertaken to determine the presence of cotinine, a metabolite of nicotine, in the saliva and gingival crevicular fluid of smokers with periodontal disease. Saliva and crevicular fluid samples were obtained from 16 habitual cigarette smokers and analyzed by High Performance Liquid Chromatography (HPLC) for the presence of cotinine. Thirteen non–smokers with periodontal disease served as controls. There was no evidence of cotinine (within our detection levels) in either the saliva or crevicular flui… Show more

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Cited by 101 publications
(95 citation statements)
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“…Indeed, it has been found that cotinine, a metabolite of nicotine, had an approximately six times higher concentration in gingival crevicular fluid compared to saliva. The mean crevicular fluid cotinine concentration was 2,457 ng/ml, while it was 424 ng/ml in saliva [McGuire et al, 1989]. In addition, saliva nicotine concentration in snuff dippers could reach as high as 9.6 mM [Hoffmann and Adams, 1981].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, it has been found that cotinine, a metabolite of nicotine, had an approximately six times higher concentration in gingival crevicular fluid compared to saliva. The mean crevicular fluid cotinine concentration was 2,457 ng/ml, while it was 424 ng/ml in saliva [McGuire et al, 1989]. In addition, saliva nicotine concentration in snuff dippers could reach as high as 9.6 mM [Hoffmann and Adams, 1981].…”
Section: Discussionmentioning
confidence: 99%
“…3,4,5,6 Some studies have demonstrated the possible absorption of nicotine by the root surfaces of smokers with periodontal disease. 7,8 In addition, fibroblasts that were exposed to nicotine Naida Zanini ASSEM (a) Márcio Luiz Ferro ALVES (a) Alessandra Barreto LOPES (a) Erivan Clementino GUALBERTO JUNIOR (a) Valdir Gouveia GARCIA (b) Letícia Helena THEODORO …”
Section: Introductionmentioning
confidence: 99%
“…5 Tobacco smoke consists of a gaseous phase which is composed of carbon monoxide, nitrogen, oxygen, and carbon dioxide as well as particulate phase containing nicotine, water and polycyclic aromatic hydrocarbons. 8 The following are the constituents of tobacco and the adverse effects caused by each one of them:…”
Section: Constituents Of Tobaccomentioning
confidence: 99%
“…5 It is metabolized in the body into two pharmacologically inactive metabolitescotinine and nicotine-N-oxide. 8 Cotinine has a longer half life of 20 hours than nicotine and has been used to estimate intake of nicotine by its measurement in plasma, urine or saliva of cigarette smokers. 10 The addictive effect of nicotine is linked to its capacity to trigger the release of dopamine -a chemical in the brain that is associated with the feeling of pleasure.…”
Section: Nicotinementioning
confidence: 99%