Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis
Yuanyuan Li,
Wenyan Xu,
Yubao Cheng
et al.
Abstract:Axonemal dynein, the macromolecular machine that powers ciliary motility, assembles in the cytosol with the help of dynein axonemal assembly factors (DNAAFs). These DNAAFs localize in cytosolic foci thought to form via liquid–liquid phase separation. However, the functional significance of DNAAF foci formation and how the production and assembly of multiple components are so efficiently coordinated, at such enormous scale, remain unclear. Here, we unveil an axonemal dynein production and assembly hub enriched … Show more
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