The thesis presents microkernel-based software-implemented mechanisms for improving the trustworthiness of computer systems based on commercial off-the-shelf (COTS) hardware that can malfunction when the hardware is impacted by transient hardware faults. The hardware anomalies, if undetected, can cause data corruptions, system crashes, and security vulnerabilities, significantly undermining system dependability. Specifically, we adopt the single event upset (SEU) fault model and address transient CPU or memory faults.We take advantage of the functional correctness and isolation guarantee provided by the formally verified seL4 microkernel and hardware redundancy provided by multicore processors, design the redundant co-execution (RCoE) architecture that replicates a whole software system (including the microkernel) onto different CPU cores, and implement two variants, loosely-coupled redundant co-execution (LC-RCoE) and closely-coupled redundant co-execution (CC-RCoE), for the ARM and x86 architectures. RCoE treats each replica of the software system as a state machine and ensures that the replicas start from the same initial state, observe consistent inputs, perform equivalent state transitions, and thus produce consistent outputs during error-free executions. Compared with other software-based error detection approaches, the distinguishing feature of RCoE is that the microkernel and device drivers are also included in redundant coexecution, significantly extending the sphere of replication (SoR).Based on RCoE, we introduce two kernel mechanisms, fingerprint validation and kernel barrier timeout, detecting fault-induced execution divergences between the replicated systems, with the flexibility of tuning the error detection latency and coverage. The kernel error-masking mechanisms built on RCoE enable downgrading from triple modular redundancy (TMR) to dual modular redundancy (DMR) without service interruption. We run synthetic benchmarks and system benchmarks to evaluate the performance overhead of the approach, observe that the overhead varies based on the characteristics of workloads and the variants (LC-RCoE or CC-RCoE), and conclude that the approach is applicable for real-world applications. The effectiveness of the error detection mechanisms is assessed by conducting fault injection campaigns on real hardware, and the results demonstrate compelling improvement.Declaration relating to disposition of project thesis/dissertation I hereby grant to the University of New South Wales or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University libraries in all forms of media, now or here after known, subject to the provisions of the Copyright Act 1968. I retain all property rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation.I also authorise University Microfilms to use the 350 word abstract of my thesis in Dissertation Abstracts International (this is applica...