Cotyledonoid dissecting leiomyoma of the uterus associated with endosalpingiosis

Driss, Maha; Zhioua, F; Doghri, Raoudha; Mrad, Karima; Dhouib, R.; Romdhane, Khaled Ben

doi:10.1007/s00404-009-1035-y

Cited by 17 publications

(15 citation statements)

References 7 publications

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“…An accurate diagnosis of CDL is challenging prior to surgery, as the distinctive grapelike (4) gross appearance of an exophytic mass resembles placental tissue and is almost always misdiagnosed clinically as an ovarian tumor or uterine sarcoma (5)(6)(7)(8). The majority of patients with CDL are diagnosed during an exploratory laparotomy (1,(9)(10)(11), and a frozen section is recommended to be used for the diagnosis of CDL (7,9). In the literature, to preserve fertility, the recommended treatment is resection of intrauterine tumors by myomectomy and extrauterine tumors by excision (1,5,12,13).…”

Section: Introductionmentioning

confidence: 99%

Cotyledonoid dissecting leiomyoma of the uterus: A report of four cases and a review of the literature

Yang

et al. 2016

Oncology Letters

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Abstract. Cotyledonoid dissecting leiomyoma (CDL), also termed Sternberg tumor, is a variant of uterine leiomyoma that is rarely diagnosed by clinical evaluation. At present, ~43 cases of CDL have been reported in the literature written in the English language. Due to the distinctive grapelike gross appearance of an exophytic mass resembles placental tissue, CDL is often misdiagnosed clinically as an ovarian tumor or uterine sarcoma. Therefore, an awareness of the features of the disease is important to prevent misdiagnosis and overtreatment. The present study reports 4 cases of CDL of the uterus that were treated at the Second Hospital of Jilin University between January 2009 and December 2011. All 4 patients in the current study presented with a palpable asymptomatic pelvic mass, which was detected during physical examinations, and cancer antigen 125 tumor marker levels that were within the normal range. The exploratory laparotomy of the 4 patients revealed lobulated tumors with a grapelike appearance extending from the lateral uterine wall into the ligament or the adjacent tissues. The frozen section and postoperative pathology were diagnosed as CDL. A total abdominal hysterectomy was performed in the first case of a 55-year-old woman that had been in menopause for 7 years. The patient was well and showed no evidence of disease subsequent to 48 months of follow-up. A total abdominal hysterectomy and right salpingo-oophorectomy were performed in the second case of a 43-year-old woman, who was well and showed no evidence of disease subsequent to 26 months of follow-up. A subtotal abdominal hysterectomy and bilateral salpingectomy were performed in the third case of a 37-year-old woman, who was well and showed no evidence of disease subsequent to 27 months of follow-up. A total abdominal hysterectomy and right-salpingectomy were performed with the removal of a retroperitoneal fibroid extension in the fourth case of a 48-year-old woman, who was well and showed no evidence of disease subsequent to 32 months of follow-up.

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Section: Introductionmentioning

confidence: 99%

Cotyledonoid dissecting leiomyoma of the uterus: A report of four cases and a review of the literature

Yang

et al. 2016

Oncology Letters

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“…However, the small number of reported cases allows no conclusion on the biological course of the lesions [14]. The combination of these gross and cytological features is quite distinctive but may lead the inexperienced pathologist or surgeon to confuse this entity with sarcoma, particularly on the gross specimen, thus leading to overtreatment [4,12].…”

Section: Discussionmentioning

confidence: 99%

“…The worrying appearance of the gross specimen is often mistaken for malignant or non-uterine lesions that may result in overtreatment [2]. It is important to be aware of this entity to prevent overly aggressive treatment of this benign smooth-muscle neoplasm [4,12].…”

Section: Discussionmentioning

confidence: 99%

“…One of the most unusual variants is called cotyledonoid dissecting leiomyoma or Sternberg tumor [2]. Originally described in 1975 by David et al [3] as ''grapelike leiomyoma'', approximately 41 cases have been reported in literature [2,[4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…The most characteristic trait of cotyledonoid dissecting leiomyoma is the distinctive combination of a malignant gross appearance with benign histology and benign clinical behavior [4,12].…”

Section: Introductionmentioning

confidence: 99%

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Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

et al. 2011

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Cotyledonoid dissecting leiomyoma ("Sternberg tumor") is an unusual type of a benign uterine smooth-muscle tumor with a distinctive gross appearance. A 57-year-old woman (gravida 7, para 6), in menopause for 3 years, presented with a 3-4-year history of increased pelvic pain. The transvaginal ultrasound scan showed a 2.5 cm sized heterogenic mass in the uterus cavity and 4 × 5 cm sized irregular contoured mass in the right lateral aspect of the uterus. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed with removal of the pelvic tumor extension. Definite pathologic examination result was cotyledonoid dissecting leiomyoma of the uterus with intravascular growth. The patient is receiving follow-up care every 6 months, and she has no evidence of disease after 22 months of follow-up. The worrying appearance of the gross specimen is often mistaken for malignant or non-uterine lesions that may result in overtreatment. It is important to be aware of this entity to prevent overly aggressive treatment for this benign smooth-muscle neoplasm.

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Cotyledonoid Leiomyoma Clinical Characteristics, Imaging Features, and Review of the Literature

Buonomo

Bussolaro

Giorda

et al. 2020

J of Ultrasound Medicine

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Cotyledonoid leiomyoma of the uterus is a rare variant of benign uterine leiomyoma. It has a favorable attitude, despite some ultrasound presentations. A bulky uterus with a heterogeneous mass with irregular margins, high vascularity, and infiltration of the myometrium can induce the suspicion of a malignant mesenchymal tumor and lead to a radical surgical treatment. If present, some imaging features may suggest this rare type of leiomyoma, thus avoiding extensive surgery, especially in young nulliparous women. We report 13 cases of cotyledonoid leiomyoma with clinical characteristics, imaging features, and a literature review.

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Cotyledonoid dissecting leiomyoma of the uterus associated with endosalpingiosis

Cited by 17 publications

References 7 publications

Cotyledonoid dissecting leiomyoma of the uterus: A report of four cases and a review of the literature

Cotyledonoid dissecting leiomyoma of the uterus: A report of four cases and a review of the literature

Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

Cotyledonoid Leiomyoma Clinical Characteristics, Imaging Features, and Review of the Literature

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