Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig

Forsberg, K.; Karlsson, J.‐A.; Theodorsson, Elvar; Lundberg, Jan M.; Persson, C. G. A.

doi:10.1016/0952-0600(88)90008-7

Cited by 162 publications

(121 citation statements)

References 15 publications

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“…Although it has been proven in many studies that inhaled capsaicin causes powerful bronchoconstriction in guinea pigs [34,35] this connection is not that evident in humans [36][37][38][39]. However, there seems to be a similar pattern in different organ systems and in different species that ethanol enhances stimuli with a potential to be irritating but to our knowledge this has not earlier been shown in human.…”

Section: Discussionmentioning

confidence: 83%

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Millqvist

Ternesten-Hasséus

Bende

2008

Pulmonary Pharmacology & Therapeutics

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To cite this version:Eva Millqvist, Ewa Ternesten-Hasséus, Mats Bende. Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity. Pulmonary Pharmacology & Therapeutics, 2008, 21 (5) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d m a n u s c r i p t 4

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Section: Discussionmentioning

confidence: 83%

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Millqvist

Ternesten-Hasséus

Bende

2008

Pulmonary Pharmacology & Therapeutics

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“…Therefore, airway contractility affects the frequency of cough induction. It is known that citric acid induced cough is produced by effects on bronchoconstriction involving with the muscarinic mechanism [2,7]. Vagal blocking by atropine aerosols significantly decreased the number of coughs in both BHS and BHR.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a larger contribution of airway C-fibers on the airway contraction was observed in BHS compared with BHR in a preliminary experiment. It is known that citric acid-induced cough is produced by the effect of citric acid on capsaicin-sensitive sensory neurons [6,7], while the bronchoconstriction induced by citric acid in guinea pigs involves a muscarinic mechanism [2,6]. It is, therefore, interesting to investigate the relationship between cough occurrence and airway sensitivity in these model animals with different muscarinic functions and the role of C-fibers in the airway.…”

Section: Discussionmentioning

confidence: 99%

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The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

et al. 2001

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Cough elicitation and major physiological factors influencing cough occurrence were investigated in congenitally bronchial-hypersensitive (BHS) and -hyposensitive (BHR) guinea pigs exposed to citric acid (0.3 M) aerosol for 10 min. The number of cough in BHS was significantly larger than in BHR, while the latency to cough in BHS was significantly shorter than in BHR. Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR. The salbutamol, atropine and capsaicin pretreatments prolonged the cough latency in BHS, but only salbutamol prolonged the latency in BHR. After salbutamol pretreatment all BHR guinea pigs exhibited cough, while 66.7% of BHS guinea pigs exhibited it. Vagal blocking by atropine suppressed coughing in both BHS and BHR. Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment. The present study demonstrated that the cough responsiveness to citric acid aerosol was significantly higher in BHS than in BHR. It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.

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“…The chest was opened to obtain the section of the trachea between the larynx and sternum, which was transferred to a dish containing warm Krebs-Henseleit buffer (NaCl 124 mmol/L, KCl 5 mmol/L, MgSO 4 1.3 mmol/L, CaCl 2 2.5 mmol/L, NaHCO 3 25 mmol/L, NaH 2 PO 4 0.6 mmol/L, and glucose 10 mmol/L). After removing excess connective tissue and fat, the trachea was dissected into 6−8 small rings of about a 2 mm width containing two or three cartilaginous segments [15] . The tracheal rings were mounted vertically in a 20 mL water-jacketed organ bath that was filled with KrebsHenseleit buffer and aerated with a mixture of 95% O 2 and 5% CO 2 at 37 °C.…”

Section: Spasmolytic Activity Tests Of Isolated Trachea In Vitromentioning

confidence: 99%

Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects

et al. 2009

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Aim:To investigate the anti-asthmatic mechanisms of the traditional Chinese medicine Pericarpium citri reticulatae (PCR). Methods: The alkaloid section (AS) of PCR was extracted using an ion exchange resin, separated, and purified into different fractions by semi-preparative HPLC. These fractions were screened for beta2-adrenergic receptor (β 2 AR) agonistic activity using rat β 2 AR-transfected CHO-CRE-EGFP cells. AS and its isolated components were characterized by ultra-performance liquid chromatography/quadrupole time-of-flight MS (UPLC/Q-Tof MS) and were evaluated for their spasmolytic and antitussive activities both in vitro and in vivo in a guinea pig model. Results: We demonstrated that the AS component responsible for activating β 2 AR signaling was synephrine. Both AS and synephrine showed significant spasmolytic effects on acetylcholine chloride (ACh)-induced contractions in isolated guinea pig trachea, and they protected against histamine-induced experimental asthma by prolonging the latent period. We further identified stachydrine as the antitussive component that could significantly reduce citric acid-induced coughing. The combination of these two bioactive compounds had a more potent spasmolytic activity in comparison with the single use of synephrine or stachydrine. Conclusion: We conclude that synephrine and stachydrine are the key components of AS that mediate asthma relief due to their synergism when used in combination.

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Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig

Cited by 162 publications

References 15 publications

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects

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