Cough hypersensitivity and chronic cough

Chung, Kian Fan; McGarvey, Lorcan; Song, Woo Jung; Chang, Anne B.; Lai, Kefang; Canning, Brendan J.; Birring, Surinder S.; Smith, Jennifer A.; Mazzone, Stuart B.

doi:10.1038/s41572-022-00370-w

Cited by 162 publications

(140 citation statements)

References 249 publications

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“…We observed that current smokers were frequent among CC subjects in both community populations, which contrasted with the observations at specialist cough clinics where most are never or non-current smokers [31,38]. This might suggest a difference in CC patient characteristics between community and specialist cough clinics.…”

Section: Discussioncontrasting

confidence: 69%

“…Interestingly, unlike in South Korea, a male predominance (54.8%) was noted in CC patients in Taiwan, which is similar to those observed at specialist cough clinics in Guangzhou, China [ 30 ]. This might be attributed to ethnic or environmental factors distinct to Taiwan and Southeast China [ 31 ]. However, the present study was not designed to investigate the sex difference, and the findings warrant further investigation.…”

Section: Discussionmentioning

confidence: 99%

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Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Song

Yu²,

Kang³

2022

Lung

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Purpose This study aimed to understand the cough characteristics and health journeys among community-based chronic cough (CC) patients, and their characteristics associated with healthcare visits. Methods A population-based cross-sectional study was conducted in 2020, using the South Korea and Taiwan National Health and Wellness Survey (NHWS) and CC surveys. Patients with current CC were defined by daily coughing for > 8 weeks in the past 12 months and currently coughing at the time of survey. The survey items pertained to CC patients’ treatment journey and cough characteristics. Results Patients with current CC in South Korea and Taiwan, respectively, had cough duration for 3.45 ± 5.13 years and 5.75 ± 7.28 years and cough severity visual analogue scale (VAS) scores of 4.50 ± 2.15 and 4.46 ± 1.92 out of 0–10 scale, with 70.3% and 57.9% having spoken with a physician about cough. Compared to CC patients who had not visited healthcare professionals for cough, those who visited reported more severe cough (VAS: 3.89 ± 1.71 vs. 4.6 ± 2.02; p = 0.009), worse cough-specific quality of life (Leicester Cough Questionnaire: 16.20 ± 3.23 vs.13.45 ± 2.68, p < 0.001), greater symptom severity (Hull Airway Reflux Questionnaire: 16.73 ± 15.16 vs. 24.57 ± 13.38; p < 0.001), and more urinary incontinence (13.6 vs. 26.5%, p = 0.027). More than 50% of patients perceived cough medication(s) as not or a little useful and 25% felt their physicians did not well understand how CC impacts their life. Conclusion Cough is frequently severe and persistent among community-based CC patients. They experience several issues in their health journey, including treatment ineffectiveness and physician’s understanding. Further efforts are warranted to reduce CC burden in the community.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Song

Yu²,

Kang³

2022

Lung

Self Cite

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“…, the presence of active airway inflammation, mucus, or acid reflux triggering sensory nerves), (2) hyper-excitability in the cough reflex circuit, and (3) impaired cough inhibition. 82 Control of peripheral triggers may be achieved with optimal treatments according to current asthma guidelines. Treatment of patients with severe eosinophilic asthma, treatments with anti-IL-5 monoclonal antibody or OCS may help to relieve cough.…”

Section: The Concept Of Treatable Traits In Severe Asthmamentioning

confidence: 99%

Evolving Concept of Severe Asthma: Transition From Diagnosis to Treatable Traits

Park

Kang

Song

et al. 2022

Allergy Asthma Immunol Res

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In recent decades, the concept of severe asthma has evolved from an umbrella term encompassing patients with high-intensity treatment needs to a clinical syndrome with heterogeneous, albeit distinct, pathophysiological processes. Biased and unbiased cluster approaches have been used to identify several clinical phenotypes. In parallel, cellular and molecular approaches allow for the development of biological therapies, especially targeting type 2 (T2) cytokine pathways. Although T2-biologics have significantly improved clinical outcomes for patients with severe asthma in real-world practice, questions on the proper use of biologics remain open. Furthermore, a subset of severe asthma patients remains poorly controlled. The unmet needs require a new approach. The “treatable traits” concept has been suggested to address a diversity of pathophysiological factors in severe asthma and overcome the limitations of existing treatment strategies. With a tailored therapy that targets the treatable traits in individual patients, better personalized medical care and outcomes should be achieved.

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“…on potential associated conditions, such as asthma, gastroesophageal reflux disease (GERD) and upper cough airway syndrome (formerly referred to as post-nasal drip syndrome) [7]. Guidelines on the management of IPF provide little in the way of recommendation for the treatment of cough.…”

mentioning

confidence: 99%

Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done

Chung

Birring

Morice

et al. 2022

Lung

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Up to 80% of patients with idiopathic pulmonary fibrosis (IPF) suffer from a chronic cough, which may be the first symptom of the disease. Cough has been reported to be an independent predictor of disease progression [1] and is associated with reduced quality of life (QoL), because from the patients' point of view, it causes physical and emotional distress with chest pain, hoarse voice, incontinence, and sleep disturbance [2,3]. In addition, cough QoL scores have been independently associated with a higher risk of hospitalisation, lung transplantation and death at 1 year [4]. Therefore, control of cough in IPF remains an important priority.Guidelines that have been published for management of refractory chronic cough (RCC) [5,6], defined as persistent cough despite thorough investigation and treatment, have not included the chronic cough of IPF, but have focused * Peter V. Dicpinigaitis

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Cough hypersensitivity and chronic cough

Cited by 162 publications

References 249 publications

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Cough Characteristics and Healthcare Journeys of Chronic Cough Patients in Community-Based Populations in South Korea and Taiwan

Evolving Concept of Severe Asthma: Transition From Diagnosis to Treatable Traits

Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done

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