Cough in Sarcoidosis

Tully, Timothy E.; Birring, Surinder S.

doi:10.1007/s00408-015-9799-2

Cited by 11 publications

(8 citation statements)

References 32 publications

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“…In pulmonary sarcoidosis, a disabling inspiratory cough can exacerbate breathlessness [3,37,[127][128][129][130] and by unconsciously restricting or slowing activity levels to avoid symptoms many patients may not recognize mild-moderate symptoms, but know that they are slower and their activity capacity is less. Musculoskeletal impairments, sarcoidosisrelated myopathy, and lower extremity joint involvement restrict activity, also making recognition of cardiopulmonary limitations less apparent.…”

Section: Cardio-respiratory Symptoms: Breathlessness and Coughmentioning

confidence: 99%

Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes

et al. 2021

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Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in clinical trials, may be the single outcome reflective of patient priorities when living with a health condition. HRQoL is a multi-dimensional concept that reflects the degree to which a health condition interferes with participation in and fulfillment of important life areas. HRQoL is intended to capture the composite degree of physical, physiologic, psychological, and social impairment resulting from symptom burden, patient-perceived disease severity, and treatment side effects. Diminished HRQoL expectedly correlates to worsening disability and death; but interventions addressing HRQoL are linked to increased survival. Sarcoidosis, being a multi-organ system disease, is associated with a diffuse array of manifestations resulting in multiple symptoms, complications, and medication-related side effects that are linked to reduced HRQoL. Diminished HRQoL in sarcoidosis is related to decreased physical function, pain, significant loss of income, absence from work, and strain on personal relationships. Symptom distress can result clearly from a sarcoidosis manifestation (e.g., ocular pain, breathlessness, cough) but may also be non-specific, such as pain or fatigue. More complex, a single non-specific symptom, e.g., fatigue may be directly sarcoidosis-derived (e.g., inflammatory state, neurologic, hormonal, cardiopulmonary), medication-related (e.g., anemia, sleeplessness, weight gain, sub-clinical infection), or an indirect complication (e.g., sleep apnea, physical deconditioning, depression). Identifying and distinguishing underlying causes of impaired HRQoL provides opportunity for treatment strategies that can greatly impact a patient’s function, well-being, and disease outcomes. Herein, we present a reference manual that describes the current state of knowledge in sarcoidosis-related HRQoL and distinguish between diverse causes of symptom distress and other influences on sarcoidosis-related HRQoL. We provide tools to assess, investigate, and diagnose compromised HRQoL and its influencers. Strategies to address modifiable HRQoL factors through palliation of symptoms and methods to improve the sarcoidosis health profile are outlined; as well as a proposed research agenda in sarcoidosis-related HRQoL.

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Section: Cardio-respiratory Symptoms: Breathlessness and Coughmentioning

confidence: 99%

Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes

et al. 2021

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“…Non-pharmacological treatment options include physical training, multidisciplinary pulmonary rehabilitation and potentially cognitive behavioral therapy [58][59][60]63] ( Table 1). Cough is present in up to 53% of sarcoidosis patients [65]. Patients with sarcoidosis have a significantly higher cough frequency compared with the normal population [66].…”

Section: Complaints and Comorbiditiesmentioning

confidence: 99%

Comprehensive Care for Patients with Sarcoidosis

Moor

Kahlmann

Culver

et al. 2020

JCM

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Sarcoidosis is a multisystem granulomatous disease, associated with significant morbidity and impaired quality of life. Treatment is aimed at recovering organ function, reducing symptom burden and improving quality of life. Because of the heterogeneity and variable disease course, a comprehensive, multidisciplinary approach to care is needed. Comprehensive care includes not only pharmacological interventions, but also supportive measures aimed at relieving symptoms and improving quality of life. The purpose of this review is to summarize the most recent knowledge regarding different aspects of care and propose a structured approach to sarcoidosis management.

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“…PROMs assessing cough in sarcoidosis include the Leicester Cough Questionnaire (LCQ) [179][180][181][182][183][184] and the cough Visual Analog Scale (cough VAS). 181,185 Several of the generic and sarcoid-specific HRQoL measures (SGRQ, 102 SHQ, 73 KSG, 92 and the SAT 53,54 ,) also include cough-related items.…”

Section: Coughmentioning

confidence: 99%

Health-Related Quality of Life in Sarcoidosis

Ndili

2020

Semin Respir Crit Care Med

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Health-related quality of life (HRQoL) describes an individual's perception of the impact of health, disease, and treatment on their quality of life (QoL). It is a reflection of how the manifestation of an illness and its treatment is personally experienced. Assessing HRQoL is particularly important in sarcoidosis because the attributable disease mortality is relatively low, and one of the major reasons for initiating treatment is to improve quality of life. HRQoL has been assessed in sarcoidosis using various generic and sarcoid-specific patient-reported outcome measures (PROMs). It is important that both the direct and indirect effects of the disease, as well as potential toxicities of therapy, are captured in the various PROMs used to assess HRQoL in sarcoidosis. This article provides a general overview of HRQoL in patients with sarcoidosis. It describes the various PROMs used to assess HRQoL in sarcoidosis and addresses the various factors that influence HRQoL in sarcoidosis. Specific attention is paid to fatigue, small fiber neuropathy, corticosteroid therapy, and other disease-specific factors that affect HRQoL in sarcoidosis. It also provides an insight into interventions that have been associated with improved HRQoL in sarcoidosis and offers suggestions for future research in this important area.

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Cough in Sarcoidosis

Cited by 11 publications

References 32 publications

Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes

Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes

Comprehensive Care for Patients with Sarcoidosis

Health-Related Quality of Life in Sarcoidosis

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