Cough reflex sensitivity after exercise challenge testing in children with asthma

Ferenc, Peter; Fabry, J.; Zatko, Tomás; Kunč, Peter; Sojak, J.; Grendár, Marian; Péčová, R

doi:10.1016/j.resp.2018.03.008

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…In contrast to healthy subjects (and healthy animals), some studies showed a lack of down regulation of CR during exercise in asthmatic patients and animal models of airway inflammation. In a study conducted in asthmatic children, CR sensitivity (capsaicin cough challenge) was assessed before and after a standardized bout of exercise (Ferenc et al, 2018). Authors showed that CR sensitivity was not significantly changed after exercise in this asthmatic population supporting a lack of evident down regulation of exercise on cough.…”

Section: Discussionmentioning

confidence: 99%

Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise

Valentin¹,

Chenuel²,

Demoulin‐Alexikova³

et al. 2020

Front. Physiol.

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Introduction: Cough is a major symptom frequently experienced during exercise, mainly in asthmatic patients. Inhaled glucocorticoids represent the keystone treatment in the management of asthma, but little is known about interactions between cough and exercise, especially in controlled patients. During exercise, cough reflex (CR) appears downregulated in healthy animal models whereas a lack of desensitization of CR has been shown in ovalbumin-sensitized animal models, mimicking asthmatic disease. Aims and Objectives:The goal of our study was to clarify the potential modulation of the CR induced by inhaled corticosteroids (CS) in ovalbumin (OVA) sensitized rabbits during artificial limb exercise.Materials and Methods: Seventeen OVA sensitized rabbits were studied. Among them, 9 were treated with CS delivered intravenously (OVA-Corticoids). The ventilatory response to direct tracheal stimulation, performed at rest and during exercise, was determined to assess the incidence and the sensitivity of the CR. Bronchoalveolar lavage (BAL) and cell counts were performed to determine the level of airway inflammation. Exercise was mimicked by electrically induced hindlimb muscular contractions (EMC).Results: Compared to rest values, EMC increased minute ventilation by 28% without any decrease in respiratory resistance (Rsr). Among 322 tracheal stimulations, 172 (53%) were performed at rest and 150 (47%) during exercise. The sensitivity of CR decreased during artificial limb exercise compared to baseline in OVA-Corticoids rabbits (p = 0.0313) while it remained unchanged in OVA rabbits (p = NS). Conclusion:Corticosteroids appear to restore the desensitization of the CR in OVA sensitized rabbits during artificial limb exercise, suggesting the potential role of airway inflammation in the pathophysiology of cough during exercise in asthmatics.

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Section: Discussionmentioning

confidence: 99%

Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise

Valentin¹,

Chenuel²,

Demoulin‐Alexikova³

et al. 2020

Front. Physiol.

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“…Further, in children (unlike adults), persistent cough sensitivity has not been found in the common causes e.g., viral infections in children with asthma [22], to significantly change post intervention e.g., post adenoidectomy [43], or in situations where cough is expected to occur (post-exercise in children with asthma [44]). Additionally, cough sensitivity has been shown to be not consistently elevated in children, e.g., C5 (concentration of capsaicin that trigger five or more coughs) was no different between children with asthma and controls (though C2 was significantly different) [45], whereas the reverse was described in children with cystic fibrosis [37].…”

Section: Why Assigning Cough Hypersensitivity Syndrome As a Diagnosti...mentioning

confidence: 99%

Cough Hypersensitivity Syndrome: Why Its Use Is Inappropriate in Children

Chang

Irwin

O’Farrell

et al. 2023

JCM

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In children and adults, chronic cough is a common symptom presenting to health professionals worldwide. It is internationally accepted that children with chronic cough should be managed with pediatric specific management guidelines. The newly proposed clinical entity of ‘cough hypersensitivity syndrome’ has gained significant attention in adult literature. Given the significant differences between childhood and adult chronic cough, including in respiratory physiology and anatomy, and cough sensitivity, we address the suitability of the use of cough hypersensitivity syndrome in children. We explore these differences between childhood and adult chronic cough, explain what cough hypersensitivity is and highlight why the term cough hypersensitivity syndrome should not be used in children.

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Cough and airway defence – Special issue of respiratory physiology and neurobiology

Plevková

Hanácek

Tatár

2018

Respiratory Physiology & Neurobiology

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Cough reflex sensitivity after exercise challenge testing in children with asthma

Cited by 5 publications

References 34 publications

Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise

Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise

Cough Hypersensitivity Syndrome: Why Its Use Is Inappropriate in Children

Cough and airway defence – Special issue of respiratory physiology and neurobiology

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