Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers

Neuschlová, Martina; Péčová, R

doi:10.2478/acm-2013-0003

Acta Medica Martiniana

2013

DOI: 10.2478/acm-2013-0003

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Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers

Martina Neuschlová¹,

R Péčová²

Abstract: A b s t r a c t Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Cough is a major symptom in some people with asthma. Cough reflex sensitivity (CRS) test with capsaicin is one of the most important method for cough studying. Cough reflex sensitivity was defined as the lowest concentration of capsaicin that elicited 2 or more (C2) and 5 or more coughs (C5). The aim of this study was to find out a cough reflex sensitivity in patients with asthma br… Show more

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2020

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Cited by 2 publications

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The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough

Brozmanová

Pavelková²

2020

Physiol Res

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An excessive, irritable, productive or non-productive coughing associated with airway inflammation belongs to pathological cough. Increased activation of airway vagal nociceptors in pathological conditions results from dysregulation of the neural pathway that controls cough. A variety of mediators associated with airway inflammation overstimulate these vagal airway fibers including C-fibers leading to hypersensitivity and hyperreactivity. Because current antitussives have limited efficacy and unwanted side effects there is a continual demand for the development of a novel more effective antitussives for a new efficacious and safe cough treatment. Therefore, inhibiting the activity of these vagal C-fibers represents a rational approach to the development of effective antitussive drugs. This may be achieved by blocking inflammatory mediator receptors or by blocking the generator potential associated with the specific ion channels. Because voltage-gated sodium channels (NaVs) are absolutely required for action potentials initiation and conduction irrespective of the stimulus, NaVs become a promising neural target. There is evidence that NaV1.7, 1.8 and 1.9 subtypes are predominantly expressed in airway cough-triggering nerves. The advantage of blocking these NaVs is suppressing C-fiber irrespective to stimuli, but the disadvantage is that by suppressing the nerves is may also block beneficial sensations and neuronal reflex behavior. The concept is that new antitussive drugs would have the benefit of targeting peripheral airway nociceptors without inhibiting the protective cough reflex.

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The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough

Brozmanová

Pavelková²

2020

Physiol Res

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Upper Airway Cough Syndrome in Pathogenesis of Chronic Cough

Lucanska¹,

Hajtman²,

Calkovský³

et al. 2020

Physiol Res

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Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The second-order neurons terminate in the pons, medulla and spinal cord and there is also the cortical and subcortical control of coughing. Upper airway cough syndrome (UACS) – previously postnasal drip syndrome - is one of the most common causes of chronic cough together with asthma and gastroesophageal reflux. The main mechanisms leading to cough in patients with nasal and sinus diseases are postnasal drip, direct irritation of nasal mucosa, inflammation in the lower airways, upper airway inflammation and the cough reflex sensitization. The cough demonstrated by UACS patients is probably due to hypersensitivity of the upper airways sensory nerve or lower airways sensory nerve, or a combination of both. Further studies are needed to clarify this mechanism.

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Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers

Cited by 2 publications

References 13 publications

The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough

The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough

Upper Airway Cough Syndrome in Pathogenesis of Chronic Cough

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