Cough Sensors. V. Pharmacological Modulation of Cough Sensors

Mazzone, Stuart B.; Undem, Bradley J.

doi:10.1007/978-3-540-79842-2_6

Cited by 40 publications

(19 citation statements)

References 133 publications

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“…Acid evoked cough may be mast cell dependent, and mast cell activation may trigger or at least modulate subsequently evoked cough [51,52]. GABA B receptor agonists can attenuate allergen-induced inflammation, perhaps through effects on mast cell activation [53,54].…”

Section: Discussionmentioning

confidence: 99%

Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: Comparison to baclofen and other GABAB receptor-selective agonists

Canning

Mori²,

Lehmann

2012

Cough

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BackgroundGastroesophageal reflux disease (GERD) is a common cause of chronic cough. Both acid and nonacid reflux is thought to play a role in the initiation of coughing and cough hypersensitivity. The GABAB receptor agonist lesogaberan was developed as a peripherally restricted anti-reflux therapy that reduces the frequency of transient lower esophageal sphincter relaxations (TLESR; the major cause of reflux) in animals and in patients with GERD. GABAB receptor agonists have also been shown to possess antitussive effects in patients and in animals independent of their effects on TLESR, suggesting that lesogaberan may be a promising treatment for chronic cough.MethodsWe have assessed the direct antitussive effects of lesogaberan (AZD3355). The effects of other GABAB receptor agonists were also determined. Coughing was evoked in awake guinea pigs using aerosol challenges with citric acid.ResultsLesogaberan dose-dependently inhibited citric acid evoked coughing in guinea pigs. Comparable effects of the GABAB receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPiA) on cough were also observed. Baclofen produced obvious signs of sedation and respiratory depression. By contrast, both lesogaberan and 3-APPiA (both inactivated centrally by GABA transporters) were devoid of sedative effects and did not alter respiratory rate.ConclusionsTogether, the data suggest that lesogaberan and related GABAB receptor agonists may hold promise as safe and effective antitussive agents largely devoid of CNS side effects.

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Section: Discussionmentioning

confidence: 99%

Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: Comparison to baclofen and other GABAB receptor-selective agonists

Canning

Mori²,

Lehmann

2012

Cough

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“…The C-fibers form a loose network in the airway mucosa with branches found in deeper lung structures [7]. The majority of C-fibers innervating the airway arise from the vagus nerve, however there is also some innervation by spinal afferent C-fibers whose cell bodies are in the DRG [30]. There are two sets of vagal C-fibers, the bronchial C-fibers which innervate the large airways and the pulmonary C-fibers which innervate the smaller, peripheral lung tissue [30].…”

Section: Reviewmentioning

confidence: 99%

Molecular signaling and targets from itch: lessons for cough

LaVinka

Dong

2013

Cough

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Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

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“…The subsequent reflex stimulation of the efferent limb results in coughing [4]. The antitussive effect of opioids generally is centrally mediated by brainstem opioid receptors [4,24], and remifentanil administration via TCI may maintain a predictable Ce with an acceptable level of bias and inaccuracy [25,26]. Therefore, the authors attempted to determine the effective remifentanil Ce for abolishing cough using the TCI in the present study.…”

Section: Discussionmentioning

confidence: 96%