Cough-Specific Quality of Life Predicts Disease Progression Among Patients With Interstitial Lung Disease

Lee, Janet; White, Eric A.; Freiheit, Elizabeth; Patel, Nina; Bascom, Rebecca; Belloli, Elizabeth A.; Bhatt, Nitin; Bhorade, Sangeeta; Case, Amy Hajari; Castriotta, Richard J.; Criner, Gerard J.; Danoff, Sonye K.; Andrade, Joao de; Desai, Alpa; Glassberg, Marilyn K.; Glazer, Craig S.; Gulati, Mridu; Gupta, Nishant; Hamblin, Mark J.; Huie, Tristan J.; Kaner, Robert J.; Kass, Daniel J.; Kim, Hyun; Kreider, Maryl; Lancaster, Lisa; Lasky, Joseph A.; Limper, Andrew H.; Montesi, Sydney B.; Mooney, Joshua J.; Morrison, Lake; Nambiar, Anoop M.; Nathan, Steven D.; Paul, T; Perez, Rafael L.; Podolanczuk, Anna J.; Raghu, Ganesh; Scholand, Mary Beth; Shifren, Adrián; Strek, Mary E.; Todd, Nevins W.; Walia, Rajat; Weight, Stephen; Whelan, Timothy; Wolters, Paul J.

doi:10.1016/j.chest.2022.03.025

Cited by 21 publications

(14 citation statements)

References 44 publications

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“…Interstitial lung disease. Chronic cough that has been reported in up to 80% of people with interstitial lung disease 58 is often severe, leads to a significantly impaired quality of life, and is associated with worse clinical outcomes 59 …”

Section: Diagnosis and Management In Adultsmentioning

confidence: 99%

Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia

Marchant,

Chang,

Kennedy

et al. 2023

Medical Journal of Australia

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IntroductionCough is the most common symptom leading to medical consultation. Chronic cough results in significant health care costs, impairs quality of life, and may indicate the presence of a serious underlying condition. Here, we present a summary of an updated position statement on cough management in the clinical consultation.Main recommendationsAssessment of children and adults requires a focused history of chronic cough to identify any red flag cough pointers that may indicate an underlying disease. Further assessment with examination should include a chest x‐ray and spirometry (when age > 6 years). Separate paediatric and adult diagnostic management algorithms should be followed. Management of the underlying condition(s) should follow specific disease guidelines, as well as address adverse environmental exposures and patient/carer concerns. First Nations adults and children should be considered a high risk group. The full statement from the Thoracic Society of Australia and New Zealand and Lung Foundation Australia for managing chronic cough is available at https://lungfoundation.com.au/resources/cicada‐full‐position‐statement.Changes in management as a result of this statement Algorithms for assessment and diagnosis of adult and paediatric chronic cough are recommended. High quality evidence supports the use of child‐specific chronic cough management algorithms to improve clinical outcomes, but none exist in adults. Red flags that indicate serious underlying conditions requiring investigation or referral should be identified. Early and effective treatment of chronic wet/productive cough in children is critical. Culturally specific strategies for facilitating the management of chronic cough in First Nations populations should be adopted. If the chronic cough does not resolve or is unexplained, the patient should be referred to a respiratory specialist or cough clinic.

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Section: Diagnosis and Management In Adultsmentioning

confidence: 99%

Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia

Marchant,

Chang,

Kennedy

et al. 2023

Medical Journal of Australia

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“…A thorough clinical history may provide useful information. In database analyses features of telomere syndrome (based on clinical history, family history or relevant haematological abnormalities) and cough‐specific quality of life were associated with reduced survival in IPF and all ILDs, respectively 49,50 …”

Section: Diagnosis Monitoring and Prognosismentioning

confidence: 99%

“…In database analyses features of telomere syndrome (based on clinical history, family history or relevant haematological abnormalities) and cough-specific quality of life were associated with reduced survival in IPF and all ILDs, respectively. 49,50 Recent studies have sought to clarify the usefulness of pulmonary function testing in predicting progression. Data from clinical trials and a single centre study found that lung function decline at 1 year predicted reduced survival in IPF, fibrotic HP and other PFILDs 51,52 and FVC decline over 3 months was associated with mortality in clinical trial participants.…”

Section: Predicting Prognosismentioning

confidence: 99%

Contemporary Concise Review 2022: Interstitial lung disease

Smith

Jenkins

2023

Respirology

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SUMMARY OF KEY POINTS Novel genetic associations for idiopathic pulmonary fibrosis (IPF) risk have been identified. Common genetic variants associated with IPF are also associated with chronic hypersensitivity pneumonitis. The characterization of underlying mechanisms, such as pathways involved in myofibroblast differentiation, may reveal targets for future treatments. Newly identified circulating biomarkers are associated with disease progression and mortality. Deep learning and machine learning may increase accuracy in the interpretation of CT scans. Novel treatments have shown benefit in phase 2 clinical trials. Hospitalization with COVID‐19 is associated with residual lung abnormalities in a substantial number of patients. Inequalities exist in delivering and accessing interstitial lung disease specialist care.

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“…Cough has been reported to be an independent predictor of disease progression [1] and is associated with reduced quality of life (QoL), because from the patients' point of view, it causes physical and emotional distress with chest pain, hoarse voice, incontinence, and sleep disturbance [2,3]. In addition, cough QoL scores have been independently associated with a higher risk of hospitalisation, lung transplantation and death at 1 year [4]. Therefore, control of cough in IPF remains an important priority.Guidelines that have been published for management of refractory chronic cough (RCC) [5,6], defined as persistent cough despite thorough investigation and treatment, have not included the chronic cough of IPF, but have focused * Peter V. Dicpinigaitis…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done

Chung

Birring

Morice

et al. 2022

Lung

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Up to 80% of patients with idiopathic pulmonary fibrosis (IPF) suffer from a chronic cough, which may be the first symptom of the disease. Cough has been reported to be an independent predictor of disease progression [1] and is associated with reduced quality of life (QoL), because from the patients' point of view, it causes physical and emotional distress with chest pain, hoarse voice, incontinence, and sleep disturbance [2,3]. In addition, cough QoL scores have been independently associated with a higher risk of hospitalisation, lung transplantation and death at 1 year [4]. Therefore, control of cough in IPF remains an important priority.Guidelines that have been published for management of refractory chronic cough (RCC) [5,6], defined as persistent cough despite thorough investigation and treatment, have not included the chronic cough of IPF, but have focused * Peter V. Dicpinigaitis

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Cough-Specific Quality of Life Predicts Disease Progression Among Patients With Interstitial Lung Disease

Cited by 21 publications

References 44 publications

Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia

Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia

Contemporary Concise Review 2022: Interstitial lung disease

Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done

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