Cough Suppression by Lidocaine

Poulton, Thomas J.; James, Francis M.

doi:10.1097/00000542-197905000-00018

Cited by 101 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An alternate mechanism is that lidocaine may act by anesthetizing peripheral cough receptors in the trachea and hypopharynx. 8 In conclusion, our study suggests that iv lidocaine 0.5 mg·kg -1 is the minimal dose to suppress fentanylinduced cough when administered one minute prior to fentanyl. Any further increase in the lidocaine dose does not reduce the incidence and severity of fentanylinduced cough.…”

Section: 212mentioning

confidence: 52%

“…[5][6][7] It has been found effective when given intravenously to suppress the cough reflex of endotracheal intubation and cough induced by manual displacement of the endotracheal tube and instillation of distilled water into the trachea in anesthetized patients. [8][9][10] In a placebo-controlled clinical study it has been demonstrated that lidocaine 1.5 mg·kg -1 decreased fentanyl-induced cough from 34.22% to 13.14% (absolute risk reduction was 21.08% and relative risk reduction was 62%) one minute prior to fentanyl administration. 11 We evaluated the minimal dose of lidocaine for suppression of fentanyl-induced cough in this randomized, prospective and placebo-controlled study.…”

Section: Objectifmentioning

confidence: 99%

“…1,3 The higher incidence of fentanylinduced cough in our study is probably because of a larger dose of fentanyl (3 µg·kg Intravenous lidocaine administration has been shown to suppress both mechanical and chemical induced airway reflexes, including the cough reflex. 5,6,[8][9][10] The dose of lidocaine required for the effective suppression of cough during tracheal intubation ranges between 1.5 to 2.0 mg·kg -1 and the duration of cough suppression was reported to last about five to eight minutes in previous studies. 5,9,10 The effect of iv lidocaine on suppression of cough during endotracheal intubation increased in a dose-dependent manner and correlated well with plasma levels.…”

Section: Objectifmentioning

confidence: 99%

See 2 more Smart Citations

Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

Pandey

Raza

Ranjan

et al. 2005

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Section: 212mentioning

confidence: 52%

Section: Objectifmentioning

confidence: 99%

Section: Objectifmentioning

confidence: 99%

See 1 more Smart Citation

Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

Pandey

Raza

Ranjan

et al. 2005

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

“…Both lidocaine and propofol have been shown to reduce airway reactiveness. 6,7 With its ß-adrenergic agonism, ephedrine has a bronchodilating effect and may be effective in suppressing the cough reflex. We investigated the effectiveness and adverse events of the three drugs in a randomized, prospective study.…”

mentioning

confidence: 99%

Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough

Lin

Sun

Chan

et al. 2004

Can J Anesth/J Can Anesth

119

View full text Add to dashboard Cite

P Pu ur rp po os se e: : The aim of this study was to evaluate the effectiveness of lidocaine, propofol and ephedrine in suppressing fentanyl-induced cough.M Me et th ho od ds s: : One hundred and eighteen patients were randomly assigned into four groups and the following medications were given intravenously: patients in Group I (n = 31) received normal saline 2 mL, Group II (n = 29) received lidocaine 2 mg·kg and Group IV (n = 28) received ephedrine 5 mg. At one minute after the study medication, fentanyl 2.5 µg·kg -1 was given intravenously within two seconds. The occurrence of cough and vital sign profiles were recorded within two minutes after fentanyl bolus by an anesthesiologist blinded to study design.R Re es su ul lt ts s: : Sixty-five percent of patients in the placebo group had cough, whereas the frequency was significantly decreased in Groups II (14%) and IV (21%). Although a numerically lower frequency of cough was noted in Group III (37%), it was not statistically different from that of the placebo group. SpO 2 decreased significantly in patients of Group III compared to placebo; one patient experienced hypoxemia necessitating mask ventilation. Patients in Group III showed a decrease in heart rate and systolic blood pressure (2 beats·min

show abstract

“…1~ A reliable technique for improving ETT tolerance while facilitating rapid and full emergence from general anesthesia would be desirable in many situations. "Deep" extubation (removal of the ETT while the patient is still in a deep plane of general anesthesia), administration of intravenous (iv) opioids or iv lidocaine, and local lidocaine spray prior to emergence have been used to diminish coughing.I, [3][4][5][6][7][8][9] Although some authors consider "deep" extubation to be an effective technique to prevent coughing during emergence from general anesthesia, 3,s loss of airway protection and aspiration is a major drawback. Intravenous lidocaine in doses of 1.0-2.0 mg.kg -1, producing a plasma lidocaine level (3 lag.m1-1) can transiently suppress coughing and other airway reflexes.…”

mentioning

confidence: 99%

In vitro diffusion of lidocaine across endotracheal tube cuffs

Huang

Tsai

Chen

et al. 1999

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purposc: Lidocaine diffuses across endotracheal tube cuffs, which may serve as a reservoir for local anesthetic to assist in the prevention of E-l-l--induced cough while emerging from general anesthesia. However, the rate of diffusion is slow. Two techniques, alkalization and warming, may increase the proportion of uncharged drug available for diffusion. The purpose of this study is to determine the effectiveness of warming alkalization or warming with alkalization on diffusion. Methods: Four preparations of lidocaine 4% were studied. Group (Gr) L -lidocaine (24~ Gr WL -warmed lidocaine (38~ Gr AL -alkalized lidocaine (24~ Gr WAL -warmed, alkalized lidocaine (38~ Twenty-four Mallinckrodt 8.0 ID (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) endotracheal tube cults were filled with 6 ml of one of the four preparations. They were then placed in a 20 ml water bath at 38~ and samples were drawn from the water bath at intervals for up to 360 rain. The lidocaine concentration in each sample was determined by gas chromatography. Results: The highest lidocaine concentration was reached in Gr WAL (410.98 ---8.53/Jg'ml -i) after 300 min and then decreased to 376.18 ___ 4.59/Jg'ml -~ after 360 rain. In Gr AL the highest concentration (235.05 _-_ 2.99 Hg.ml -I) was reached after 360 rain. Lidocaine concentrations in Gr L and WL after 360 min were 3.19 __-I. 16 Hg-ml -I and 4.32 +-2.02/lg'ml -I respectively. Condition: Alkalization with or without warming, but not warming alone, promotes lidocaine diffusion from endotracheal tube cuff.Obje~df : La lidocaine diffuse, lentement toutefois, au travers des ballonnets des tubes endotrach~aux. Les balIonnets peuvent servir de r&ervoir ~ ranesth&ique local et participer ~ la prevention de la toux induite par le TET pendant la r&up&ation de I'anesth~sie g6n&ale. I'alcalinisation et le r&hauffement peuvent accro~tre la proportion de m~dicament susceptible de diffuser. I'objectif de la pr&ente &ude est de d&erminer I'eflicacit~ du r&hauffement, seul ou avec alcalinisation, sur la diffusion. M&hode : On a &udi~ quatre preparations de lidocaine. Le groupe (Gr) L -lidoca'ine (24 ~ Gr LR -lidoca'ine r&hauff& (38 ~ Gr LA -lidoca/ne alcalinis& (24 ~ Gr LRA -lidocaine r&hauff&, alcalinis& (38 ~ Vingtquatre tubes endotrach6aux ~ ballonnets Mallinckrodt de DI 8,0 (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) ont fitfi remplis de 6 ml de rune des preparations. Plac& ensuite dans un bain d'eau de 20 ml ~ 38 ~ on en a ensuite retir~ des &hantillons ~ des intervalles pouvant aller jusqu'~ 360 min. La concentration de lidoca'ine a ~t~ d6termin6e par chromatographie en phase gazeuse. R&ultats : La plus forte concentration de lidocaine a ~t~ atteinte dans le Gr LRA, 410,98 ---8,53 Hg'ml-', apr~s 300 rain, puis elle a baiss~ ~ 376, 18 ---4,59 ~/g-ml-' apr& 360 rain. Dans le Gr LA, la concentration maximale &ait de 235,05 ___ 2,99/ag.ml-' apt& 360 rain. Dans les Gr Let LR, la lidoca'l'ne ~tait, apr& 360 rain de 3, 19 _ I, 16/ag.ml-...

show abstract

Cough Suppression by Lidocaine

Cited by 101 publications

References 0 publications

Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough

In vitro diffusion of lidocaine across endotracheal tube cuffs

Contact Info

Product

Resources

About