Could cheese be the missing piece in the French paradox puzzle?

Petyaev, Ivan M.; Bashmakov, Yuriy K.

doi:10.1016/j.mehy.2012.08.018

Cited by 28 publications

(25 citation statements)

References 43 publications

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“…On the other hand, recently it has been reported that excessive cheese consumption, despite high lipid content, reduces LDL cholesterol when compared with butter intake of equal fat content [16]. It is also possible that "yellow cheese consumption" is a proxy measure of some unmeasured lifestyle characteristic.…”

Section: Diet and Mortalitymentioning

confidence: 99%

The effect of selected lifestyle factors and diet on mortality of men with documented physical fitness in the city of Łódź

Śmigielski

Jegier

Hanke

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Introduction: It is still uncertain if having at least moderate physical fitness is a necessary and sufficient condition for lowering the risk of death. The aforementioned statement constituted the basis for undertaking the study concerning the effect of particular health-related behaviours on the likelihood of survival in subjects with a moderate and high physical fitness. Materials and Methods: The study sample, i.e. 204 men aged 30-59 years living in Łódź, Poland, was selected within the CINDI WHO Programme and examined over the years 1980-1990 and 2003-2004. In each subject approximate values of one week energy expenditures associated with performing physical exercise of at least moderate intensity (> 1000 kcal/week) were estimated. Physical efficiency in the study group was evaluated basing on the results of the submaximal effort test. Information about selected socio-demographic characteristics, consumption of alcohol, cigarette smoking and diet was gathered. The vital status of the examined sample was checked in 2009. The Cox proportional hazards regression model was used to identify factors which influence the survival of examined population. Results: The probability of death was more than fourfold higher in the case of individuals who eat "beef or pork meat", as compared to those who consumed these products rarely or never. On the other hand, the subjects who declared regular consumption of yellow cheese had nearly fourfold lower death probability. Current smoking was found to be a significant negative risk factor while moderate consumption of beer a protective one. The level of physical fitness (V O2max ) did not significantly influence mortality. Conclusions: The results of the performed analyses indicate negative effect associated with consumption of beef/pork meat and smoking. Furthermore, the data pertaining to the consumption of yellow cheese as a potent protective factor for men's health requires further verification. The possibility that it is some lifestyle proxy rather than a causal factor cannot be excluded.

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Section: Diet and Mortalitymentioning

confidence: 99%

The effect of selected lifestyle factors and diet on mortality of men with documented physical fitness in the city of Łódź

Śmigielski

Jegier

Hanke

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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“…The ''dairy products" hypothesis was formulated in Medical Hypotheses three years ago as ''the missing piece of the French paradox puzzle" [6]. This hypothesis was based on the observation that French people consume a lot of dairy products, and especially cheese (>26 kg/capita/year) [6].…”

Section: Introductionmentioning

confidence: 99%

“…This hypothesis was based on the observation that French people consume a lot of dairy products, and especially cheese (>26 kg/capita/year) [6]. In summary, information was gathered showing that milk-borne bioactive peptides, those inhibiting angiotensin-I converting enzyme and others regulating thrombotic functions, blood coagulation and microcirculation contribute to reduced blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Dairy products and the French paradox: Could alkaline phosphatases play a role?

Lallès

2016

Medical Hypotheses

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“…In fact, cheese, while known to be a high-fat dairy product, has been shown to induce various healthpromoting effects in several studies. For example, European countries with high cheese consumption, such as France, Switzerland, and Greece, also appear to have a lower incidence of cardiovascular disease and mortality (Petyaev and Bashmakov 2012). However, the full health benefits of cheese consumption and the underlying physiological mechanisms responsible for these effects are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Cheese consumption prevents fat accumulation in the liver and improves serum lipid parameters in rats fed a high-fat diet

Higurashi

Ogawa

Nara

et al. 2016

Dairy Sci. & Technol.

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Cheese consumption has been reported to reduce the risk of metabolic syndrome; however, the mechanisms by which cheese prevents these disorders are not fully understood. The purpose of this study was to examine the effects of cheese consumption on lipid accumulation in the liver as well as to evaluate various serum lipid parameters. Two groups (n = 7) of male Fischer-344 rats were fed the following high-fat diets for 9 weeks: AIN76-modified 20% fat diet containing casein and butter oil (control diet) or the 20% fat diet containing a freeze-dried cheese powder (cheese diet). Blood samples, liver tissue, and fecal specimens were collected and analyzed. Cheese consumption for 9 weeks reduced the accumulation of triglyceride and cholesterol in the liver (P = 0.016 and P < 0.001, respectively), as well as the serum non-highdensity lipoprotein (non-HDL) cholesterol concentration (P = 0.013). In contrast, cheese consumption increased the serum HDL concentration with statistical tendency (P = 0.086). We also observed an increase in the serum adiponectin concentration at week 9 in rats fed the cheese diet (P = 0.029). Furthermore, cheese consumption also increased fat excretion in the feces (P < 0.001). Taken together, our results suggest that cheese mediates various beneficial effects for preventing the development of metabolic syndrome by suppressing the accumulation of fat in the liver.

show abstract

Could cheese be the missing piece in the French paradox puzzle?

Cited by 28 publications

References 43 publications

The effect of selected lifestyle factors and diet on mortality of men with documented physical fitness in the city of Łódź

The effect of selected lifestyle factors and diet on mortality of men with documented physical fitness in the city of Łódź

Dairy products and the French paradox: Could alkaline phosphatases play a role?

Cheese consumption prevents fat accumulation in the liver and improves serum lipid parameters in rats fed a high-fat diet

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