Cloud systems could help companies to optimize the structure and operation of supply chain and improve organizational performance into a higher level. In this chapter, the advantages and basic operation methods of cloud computing are analyzed, and the essential factors that contribute to the success of the cloud system are evaluated through some business examples. Supply chain firms rely on cloud system to share resources and to achieve integration through the Internet. Cloud systems could transform customer relationship and internal operation to achieve sustainable competitive advantages. Cloud services are providing the ability to share information to the supply chain at any time anywhere. This chapter explores the relationship between supply chain organization and cloud computing. This chapter also discusses the benefits and advantage to evaluate of cloud system in successful factors.