Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?: A rare case report

Purwoto, Gatot; Nuryanto, Kartiwa Hadi; Wibowo, Taufik Agung; Hellyanti, Tantri; Syaharutsa, Danny Maesadatu; Julianti, Kelli

doi:10.1016/j.ijscr.2022.107083

Cited by 2 publications

(5 citation statements)

References 10 publications

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“…8 Primary SRCCC is a rare malignancy, with only about 30 cases reported in the English literature. [4][5][6][7] According to Hamada et al, SRCC in its pure or predominant form is extremely rare, and SRCC usually coexists with the usual endocervical type or intestinal type. 7 Moreover, they also stated that the presence of SRCC components can be used to make a diagnosis of SRCC, and six previous cases were diagnosed as SRCCC using only the biopsy specimen.…”

Section: Discussionmentioning

confidence: 99%

“…Primary SRCCC is a rare malignancy, with only about 30 cases reported in the English literature 4–7 . According to Hamada et al, SRCC in its pure or predominant form is extremely rare, and SRCC usually coexists with the usual endocervical type or intestinal type 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there have only been a few cases of primary SRCCC, and details about its pathogenesis and prognosis remain unknown. [4][5][6][7] Systemic sclerosis (SSc) is an autoimmune disease characterized by the distinctive pathogenetic triad of microvascular damage, dysregulation of innate and adaptive immunity, and generalized fibrosis in multiple organs. 8 Based on the extent of the skin involvement, there are two subsets of SSc: limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc).…”

Section: Introductionmentioning

confidence: 99%

“…The presence of SRCC in the uterine cervix (SRCCC) is frequently reported as a metastasis from other organs such as the stomach, breast, and colon. Therefore, there have only been a few cases of primary SRCCC, and details about its pathogenesis and prognosis remain unknown 4–7 …”

Section: Introductionmentioning

confidence: 99%

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A rare case of signet ring cell carcinoma with diffuse cutaneous systemic sclerosis: A case report

Sano,

Yoshida,

Hibi

et al. 2023

J of Obstet and Gynaecol

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Systemic sclerosis, an autoimmune disease characterized by fibrosis and vasculopathy of the skin and other multiple organs has been associated with an increased risk of malignancy. We present the case of a 74‐year‐old woman who had diffused cutaneous systemic sclerosis and uterine cervical cancer. The patient was initially diagnosed with stage IIB squamous cell carcinoma and concurrent chemoradiotherapy was planned. However, cisplatin could not be administered due to acute renal failure, so the patient was treated solely with radiotherapy. However, complications of systemic sclerosis progressed rapidly, and the patient died 63 days later from pulmonary edema. An autopsy later revealed that uterine cervix had primary signet ring cell carcinoma. We suspected that this patient had a combination of signet ring cell carcinoma and squamous cell carcinoma, with squamous cell carcinoma disappearing after radiotherapy. This case highlighted the importance of systemic management for cancers associated with systemic sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A rare case of signet ring cell carcinoma with diffuse cutaneous systemic sclerosis: A case report

Sano,

Yoshida,

Hibi

et al. 2023

J of Obstet and Gynaecol

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“…Given the histological finding of a signet ring cell carcinoma in the uterine cervix, it is necessary to know the patient’s oncological history, analyse the clinical presentation, the physical examination, the results of the imaging studies, the endoscopic findings to conclude by exclusion that it is a PSRCC [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Primary signet ring cell carcinoma of the cervix: case report and literature review

Abad-Licham,

Cotrina,

Guerrero

et al. 2024

ecancer Journal

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Objective To report an infrequent case of primary signet ring cell carcinoma of the cervix (PSRCC), review the literature and evaluate the clinicopathological characteristics. Material and methods A 51-year-old female patient, with 3 years of disease characterised by gynaecologic bleeding and pelvic pain. On examination, cervix replaced by tumour and infiltrated parametria; with cytology and histology of adenocarcinoma with cells in a signet ring pattern. Disease extension studies were negative. Classified as PSRCC stage IIIB, chemotherapy and radiotherapy were indicated, but the patient died a month later. The bibliographic search included publications up to July 2023. Results 32 cases with a mean age of 47.6 years were identified. The most frequent symptoms were uterine bleeding and abdominal and pelvic pain. The initial stages were treated surgically, some with adjuvant chemotherapy and/or radiotherapy, with favourable responses; a difference from advanced cases. The average survival was 17.6 months. Conclusion PSRCC is rare, with 32 cases reported according to the review. The expression with immunohistochemical and molecular techniques for the human papilloma virus can help confirm the gynaecological primary, but its diagnosis is one of exclusion, since its morphological pattern is related to other primaries, mainly digestive.

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Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?: A rare case report

Cited by 2 publications

References 10 publications

A rare case of signet ring cell carcinoma with diffuse cutaneous systemic sclerosis: A case report

A rare case of signet ring cell carcinoma with diffuse cutaneous systemic sclerosis: A case report

Primary signet ring cell carcinoma of the cervix: case report and literature review

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