Could CRISPR be the solution for gene editing’s Gordian knot?

CRISPR-Cas12 and Cas13: the lesser known siblings of CRISPR-Cas9

“…CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) technology has become a keystone in genetic engineering as an invaluable tool to understand precise and molecular mechanisms of disease development, drug resistance and single-cell biology (Fang and Wang 2016;Wang and Wang 2017;Wang et al 2018). CRISPR is divided into class I and class II, with 6 divisions and finally over 30 different subtypes .…”

The future is now: cutting edge science and understanding toxicology

“…This is reflected in the high number of citations for this paper (already nine times in Scopus). In addition, a very useful overview of the potential caveats associated with CRISPR/Cas9 was provided by Fang and Wang in CBT (Fang and Wang 2016). These authors mentioned the possible need to implement a Breversal drive^to overwrite initial gene modifications and reverse unwanted effects.…”

Keeping our eyes on CRISPR: the “Atlas” of gene editing

“…The ethical dilemmas CRISPR faces have been mentioned previously in multiple publications (Fang and Wang 2016; Organizing Committee for the International Summit on Human Gene Editing 2015; Wang et al 2018) and, however, were centered around the importance of cautious experimentation and suitable framework as well as the need for international guidelines regarding gene editing in human germlines. The ethical aspect of gene editing has come under public scrutiny when gene-edited twin girls were born in China in November 2018.…”