Could cross‐immunological reactivity to <i>Trypanosoma cruzi</i> antigens be considered a rational strategy for designing vaccines against cancer?

Novaes, Rômulo Dias; Gonçalves, Reggiani Vilela; Caldas, Ivo Santana

doi:10.1002/ijc.30247

Cited by 1 publication

(2 citation statements)

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“…Probably, the observed differences are highly dependent on the dose used of parasite lysates or proteins; however, the existence of: 1) antibodies capable to recognize both parasite and host Ags and, 2) cellular autoimmune events suggests that tumor cells and T. cruzi likely present similar (or even identical) epitopes to immune cells (Gironès et al, 2005;Novaes et al, 2016;Ubillos et al, 2016). Thus, the infection likely induces a cross-immune response against TAgs (Zhigunova et al, 2013;Campo et al, 2014).…”

Section: Cross-reactivity Between T Cruzi and Tumors The Molecular Mi...mentioning

confidence: 99%

“…Additionally, Garcia et al (1996) observed that the number of distal colon carcinomas in rats with experimental megacolon (without infection) was lower than in the absence of megacolon. Hence, a potential relationship between megacolon and oncoprotection at the colon level likely exists, perhaps due to the imbalance of neuroendocrine mediators in the denervated colon influencing tumor cell metabolism, survival, and proliferation (Novaes et al, 2016).…”

Section: Altered Neuronal Signalingmentioning

confidence: 99%

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Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

Kaufman,

Farré,

Biscari

et al. 2023

Front. Cell Dev. Biol.

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Considering the extensive and widespread impact on individuals, cancer can presently be categorized as a pandemic. In many instances, the development of tumors has been linked to endemic microbe infections. Among parasitic infections, Trypanosoma cruzi stands out as one of the most extensively discussed protozoans in the literature that explores the association between diseases of parasite origin and cancer. However, the effective association remains an unsolved paradox. Both the parasite, along with protozoan-derived molecules, and the associated antiparasitic immune response can induce alterations in various host cell pathways, leading to modifications in cell cycle, metabolism, glycosylation, DNA mutations, or changes in neuronal signaling. Furthermore, the presence of the parasite can trigger cell death or a senescent phenotype and modulate the immune system, the metastatic cascade, and the formation of new blood vessels. The interaction among the parasite (and its molecules), the host, and cancer undoubtedly encompasses various mechanisms that operate differentially depending on the context. Remarkably, contrary to expectations, the evidence tilts the balance toward inhibiting tumor growth or resisting tumor development. This effect is primarily observed in malignant cells, rather than normal cells, indicating a selective or specific component. Nevertheless, nonspecific bystander mechanisms, such as T. cruzi’s adjuvancy or the presence of proinflammatory cytokines, may also play a significant role in this phenomenon. This work aims to elucidate this complex scenario by synthesizing the main findings presented in the literature and by proposing new questions and answers, thereby adding pieces to this challenging puzzle.

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Section: Cross-reactivity Between T Cruzi and Tumors The Molecular Mi...mentioning

confidence: 99%

Section: Altered Neuronal Signalingmentioning

confidence: 99%

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

Kaufman,

Farré,

Biscari

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Could cross‐immunological reactivity to Trypanosoma cruzi antigens be considered a rational strategy for designing vaccines against cancer?

Cited by 1 publication

References 9 publications

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

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