Could Decreased Reporting of Suspected Adverse Reactions Generate Future Safety Concerns?

Ferrara, Francesco; Mancaniello, Carolina; Nava, Livia; Salierno, Alessandra; Casillo, Raffaele; Trama, Ugo; Nava, Eduardo; Vitiello, Antonio

doi:10.1177/00185787211069040

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…This increase, occurring in the post-COVID-19 pandemic period, contrasts with global campaigns to reduce consumption and preserve antimicrobial efficacy. Assessing and monitoring antibiotic prescriptions is crucial to manage antibiotic resistance in hospitalized patients [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Studies in the literature demonstrate that limiting antibiotic use to clinical cases requiring specific anti-infective interventions is essential to counteract antibiotic resistance, leading to fewer therapeutic failures.…”

Section: Discussionmentioning

confidence: 99%

Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance

Ferrara,

Pasquinucci,

Capuozzo

et al. 2024

Pharmaceuticals

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Introduction: The emergence and spread of drug-resistant pathogens due to the improper use of antibiotics have become increasingly apparent in recent years. Objective: This retrospective comparative analysis aimed to assess and compare antibiotic prescription trends in Italy across two different regions based on geographic area and healthcare structure. One region represents a large hospital institution, while the other represents a populous local Italian health agency. The study also examined the impact of documented antibiotic stewardship programs and efforts to promote responsible antibiotic use at all levels, in alignment with international goals. Antibiotic consumption data were collected from the Umberto I Polyclinic Hospital and the ASL Napoli 3 South Local Health Agency. Methods: To compare consumption between regions, a standardized comparison using the Defined Daily Dose (DDD) was employed. The internal management system of each healthcare facility records all prescriptions and drug dispensations, and these data were extrapolated for this retrospective study. Results: A comparative assessment between the first half of 2022 and 2023 (January–June) highlighted a significant increase in beta-lactam antibiotic consumption, showing a twofold rise compared to the previous year’s term. Regarding prescription averages, there was a noticeable increase of +29.00% in hospitalizations and +28.00% in hospital discharges within the ASL Napoli 3 South. Conversely, at Policlinico Umberto I, there was a marginal increase of +1.60% in hospitalizations and a decrease of −7.40% in hospital discharges. Conclusions: The study offers valuable insights into expenditure patterns and antibiotic consumption, underscoring the need for enhanced prescribing practices and awareness campaigns to address the issue of antibiotic resistance. The findings stress the importance of implementing international guidelines to combat the growing threat of antibiotic resistance and ensure the effective management of infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance

Ferrara,

Pasquinucci,

Capuozzo

et al. 2024

Pharmaceuticals

Self Cite

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“…From minor side effects to serious problems that might result in morbidity and mortality, these reactions can range widely. Patient safety and healthcare expenditures are significantly impacted by ADRs (Ferrara et al, 2022). For instance, individuals who experience ADRs could need additional diagnostic procedures, specialized advice, or additional medications to treat the side effects (Patton and Borshoff, 2018).…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomics as a Tool in Addressing Genetic VariationDependent Adverse Drug Reactions

Anunobi

2024

dujopas

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Adverse drug reactions (ADRs) are a cause of discontinuing drug development and withdrawal from market, as well as a very common source of morbidity and mortality. Genetic variables may be the primary predictor of drug response for certain medications, but they are estimated to account for 15– 30% of the variability in drug response. Many factors can contribute to adverse drug reactions, including genetics and drug targeting/delivery. Genetic markers, such as single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes, drug targets, and human leukocyte antigen (HLA) genotypes, have been associated with an increased risk of ADRs. Pharmacogenomics is the study of the genetic variation in the way that different people react to different pharmaceuticals, including variations in the risk of adverse drug reactions, dose requirements, and efficacy. The implementation of genetic data for predicting responses to medications and ADRs is becoming a reality in clinical practice, offering the potential to reduce the incidence of ADRs and improve patient outcomes. As pharmacogenomic research continues to advance, it holds great promise for enhancing drug safety and efficacy, ultimately leading to more tailored and effective therapeutic interventions.

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The diabetic patient between sustainability and effectiveness of new treatments

Ferrara,

Zovi,

Langella

et al. 2023

J Diabetes Metab Disord

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Could Decreased Reporting of Suspected Adverse Reactions Generate Future Safety Concerns?

Cited by 6 publications

References 5 publications

Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance

Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance

Pharmacogenomics as a Tool in Addressing Genetic VariationDependent Adverse Drug Reactions

The diabetic patient between sustainability and effectiveness of new treatments

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