2012
DOI: 10.1152/japplphysiol.01467.2011
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Could dynamic ventilation waveforms bring about a paradigm shift in mechanical ventilation?

Abstract: TODAY, MECHANICAL VENTILATORS are the primary life-support systems routinely used in every intensive care unit around the world. Mechanical ventilators first reached widespread use in the United States during the poliomyelitis epidemic in the 1940-1950s. Initial devices, known as "iron lungs," provided

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Cited by 5 publications
(4 citation statements)
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“…This approach is intended to distribute surfactant from the bulk across the air-liquid interface and has demonstrated a 50% improvement in surfactant function in in vitro experiments [31]. These findings suggest that ventilation waveforms may be designed to maximize the efficacy of pulmonary surfactant and thus to minimize VILI [41]. …”
Section: Surfactant Biophysicsmentioning
confidence: 99%
“…This approach is intended to distribute surfactant from the bulk across the air-liquid interface and has demonstrated a 50% improvement in surfactant function in in vitro experiments [31]. These findings suggest that ventilation waveforms may be designed to maximize the efficacy of pulmonary surfactant and thus to minimize VILI [41]. …”
Section: Surfactant Biophysicsmentioning
confidence: 99%
“…It demonstrated a 50% improvement in surfactant function [185]. These findings suggest that ventilation waveforms could be designed to maximize the efficacy of pulmonary surfactant and thereby minimise the risk of VILI [186].…”
Section: Viscous Material/bolus Surfactantmentioning
confidence: 84%
“…This paper considers, for the first time, a composite between these two approaches, constructing a theoretical model for mechanical ventilation of an initially flooded network of airways incorporating a detailed understanding of the mechanics of single airway recruitment [ 14 ] and the influence of airway wall elasticity and recruitment across bifurcations (challenges identified by Amin & Suki [ 30 ]). To capture lung inhomogeneity [ 31 ], both within and between individuals, the network is assumed to have a prescribed statistical distribution of geometric properties, sampling the cross-sectional area of each constituent airway from a normal distribution about a given mean for that generation.…”
Section: Introductionmentioning
confidence: 99%