Fibromyalgia, a chronic disease that causes disabling pain, is on the rise worldwide. Over the last 6 years, the University of São Paulo, in Brazil, has developed equipment capable of synergistically emitting Photobiomodulation and Ultrasound. Furthermore, a new approach to treatment methodology, using the palms of the hands as a "gateway", has achieved better results. This new approach based on structural changes in the palms. The objective of this work is to evaluate possible differences in the intracranial compliance of patients that allow us to understand possible changes in the pain regulation center. The assessment of intracranial compliance was carried out using Brain4care technology, a mechanical extensometer that is connected to a mechanical device, in direct contact with the surface of the scalp in the temporal frontal-parietal region of the skull, being able to detect small cranial oscillations resulting from pressure. intracranial. Monitoring was carried out in periods before the intervention, during the intervention and after the intervention, totaling 20 minutes. The intervention was carried out using Laser and Ultrasound equipment. It was possible to observe the modulation of intracranial compliance, reducing values when above ideal, increasing the time considered within the ideal, Reduction of pain according to visual analogue scale and Improvement of quality of life according to the Fibromyalgia Impact Questionnaire. Based on these observations, the synergistic treatment of photobiomodulation and ultrasound promoted pain reduction and improved quality of life, allowing the patient's full reintegration into family, society and the reestablishment of their professional activities.