Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

Moreno, Manuel Sánchez; Casado, N.; Urrea-París, M. A.; Rodrı́guez-Caabeiro, F.

doi:10.1007/s00436-001-0519-x

Cited by 23 publications

(21 citation statements)

References 5 publications

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“…In conclusion, the results obtained in the IVM+ABZ chemoprophylactic treatment of hydatidosis support the suggestions of Casado et al (1989) and Casado et al (2002) in relation to the possible efficacy of IVM and IVM+ABZ against protoscolices. In spite of this, IVM is not effective in vivo; however, the combination of this drug with ABZ could be considered very effective in the chemoprophylactic treatment of hydatidosis.…”

Section: Discussionsupporting

confidence: 90%

Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

et al. 2002

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The efficacy of a combination of ivermectin (IVM) and albendazole (ABZ) used as a chemoprophylactic treatment and as treatment of secondary hydatidosis is described for the first time. IVM treatment alone was not effective against Echinococcus granulosus, either when the protoscolices were recently inoculated or when they had developed to the metacestode stage. However, the efficacy of IVM and ABZ when used in combination as a prophylactic treatment was 95.72% and 87% with respect to the number and the wet weight of cysts, respectively. These results were higher than in the treatment of secondary hydatidosis, which were 44.8% and 45.26%, respectively. The ultrastructural changes in the germinal layer of the cysts after the treatments are also described.

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Section: Discussionsupporting

confidence: 90%

Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

et al. 2002

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“…In two studies involving the hydatid organism, Echinococcus granulosus, greater surface disruption was demonstrated with combinations of praziquantel plus albendazole and ivermectin plus albendazole than with the individual drugs (Urrea-Paris et al 2000;Casado et al 2002). There have been more transmission electron microscope studies and the greater severity of morphological changes induced by the particular combination of drugs compared with either drug on its own has been interpreted as synergism (Urrea-Paris et al 2000;Moreno et al 2001Moreno et al , 2002Casado et al 2002;Mehlhorn et al 2003;Stettler et al 2004).…”

Section: Discussionmentioning

confidence: 85%

“…There have been more transmission electron microscope studies and the greater severity of morphological changes induced by the particular combination of drugs compared with either drug on its own has been interpreted as synergism (Urrea-Paris et al 2000;Moreno et al 2001Moreno et al , 2002Casado et al 2002;Mehlhorn et al 2003;Stettler et al 2004). It is difficult to quantify morphological changes: Other parameters that have been used to assess synergism include speed of elimination (Mehlhorn and Harder 1997), motility (Nicolay et al 2000), viability (Urrea-Paris et al 2000;Casado et al 2002), parasite weight (Stettler et al 2004), worm burden (Bennet et al 1980), and larval numbers (Bennet et al 1978).…”

Section: Discussionmentioning

confidence: 93%

Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke

et al. 2006

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A study has been carried out to investigate the morphological effects of half-strength triclabendazole (TCBZ), half-strength clorsulon, and a combination of these two drugs against mature Fasciola hepatica. The Cullompton TCBZ-susceptible isolate was used for these experiments. Flukes were incubated for 24 h in vitro in TCBZ sulphoxide (7.5 microg/ml), clorsulon (5 microg/ml), or a combination of the two drugs. For the in vivo experiment, rats were dosed with TCBZ (6.25 mg/kg body weight), clorsulon (5 mg/kg body weight), or a combination of the two drugs and flukes recovered after 48 h. Surface changes to the flukes were assessed by scanning electron microscopy. Treatment with the combination of drugs produced greater disruption to the flukes than the individual drugs at half-strength, both in vivo and in vitro. Disruption to the tegument of the flukes induced by the individual drugs at half-strength was relatively minor and less than that caused by the drugs at full-strength. The results suggest that there are additive effects between TCBZ and clorsulon, which may be indicative of synergy: the use of drug combinations would be of value in the treatment of triclabendazole-resistant fluke.

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“…However, albendazole is poorly absorbed in the intestinal tract, attaining low levels of hepatic concentration and its high cost, serious adverse reactions, and resistance are limitations. Therefore, a search for new drugs is needed for the treatment of echinococcosis (3)(4)(5)(6)(7). In China, especially the Tibet areas, S. moorcroftiana seeds are commonly used for the treatment of verminosis (1,2).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with echinococcosis taking albendazole may have serious adverse reactions such as encephalitis syndrome, influenza-like syndrome, allergic purpura, drug rash, etc., and the treatment is not cost effective. Moreover, Echinococcus granulosus protoscolices have developed resistance to albendazole (3)(4)(5)(6)(7). Therefore, the search for new drugs continues.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of Sophora moorcroftiana alkaloids in combination with albendazole in mice experimentally infected with protoscolices of Echinococcus granulosus

Bao

Wan

et al. 2007

Braz J Med Biol Res

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The objective of the present study was to determine if the combination of alkaloids from Sophora moorcroftiana seeds and albendazole might be effective in the treatment of experimental echinococcosis in female NIH mice (6 weeks old and weighing 18-20 g, N = 8 in each group) infected with protoscolices of Echinococcus granulosus. Viable protoscolices (N = 6 x 10 3 ) were cultured in vitro in 1640 medium and mortality was calculated daily. To determine the in vivo efficacy, mice were inoculated intraperitoneally with viable protoscolices and then treated once daily by gavage for three months with the alkaloids (50 mg kg -1 day -1 ) and albendazole (50 mg kg -1 day -1 ), separately and in combination (both alkaloids at 25 mg kg -1 day -1 and albendazole at 25 mg kg -1 day -1 ). Next, the hydatid cysts collected from the peritoneal cavity of the animals were weighed and serum IL-4, IL-2, and IgE levels were analyzed. Administration of alkaloids to cultured protoscolices showed significant dose-and time-dependent killing effects. The weight of hydatid cysts was significantly decreased upon treatment with each drug (P < 0.01), but the decrease was more prominent and the rate of hydatid cyst growth inhibition was much higher (76.1%) in the group receiving the combined treatments (18.3 ± 4.6 mg). IL-4 and total IgE were decreased (939 ± 447 pg/mL and 2.03 ± 0.42 IU/mL, respectively) in serum from mice treated with alkaloids and albendazole compared with the untreated control (1481 ± 619 pg/mL and 3.31 ± 0.37 IU/mL; P < 0.01). These results indicate that S. moorcroftiana alkaloids have protoscolicidal effects and the combination of alkaloids and albendazole has significant additive effects.

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Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

Cited by 23 publications

References 5 publications

Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke

Therapeutic effects of Sophora moorcroftiana alkaloids in combination with albendazole in mice experimentally infected with protoscolices of Echinococcus granulosus

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