Could moderate alcohol intake be recommended to improve vaccine responses?

Messaoudi, Ilhem; Pasala, Sumana; Grant, Kathleen A.

doi:10.1586/14760584.2014.924405

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…The impacts of alcohol consumption on health are complex and modulated by several factors such as pattern and amount of drinking, genetics, the organ system studied, and the sex and age of the user27. Regular heavy consumption (≥3 drinks a day in men) causes suppression of innate immunity28, whereas moderate consumption (<2 drinks a day for men)29 may enhance the effects of vaccines27 and increase intestinal permeability30, which can lead to immune recognition of self-antigens31. Here, the effects of alcohol were not considered beneficial, since autoantibodies can mark future autoimmunity.…”

Section: Discussionmentioning

confidence: 99%

Demographic associations for autoantibodies in disease-free individuals of a European population

Haller-Kikkatalo

Alnek

Metspalu

et al. 2017

Sci Rep

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The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.

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Section: Discussionmentioning

confidence: 99%

Demographic associations for autoantibodies in disease-free individuals of a European population

Haller-Kikkatalo

Alnek

Metspalu

et al. 2017

Sci Rep

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“…In two studies, we found that those who abstain from consuming alcohol are at greater risk for colds than those who drink one to four drinks a day. Because we did not have heavier drinkers in our studies, we cannot conclude anything about the potential effects of consuming greater doses, although the evidence on alcohol abuse and immunity leads us to expect that greater numbers of drinks would be associated with greater risk (Barr et al, 2016; Messaoudi, Pasala, & Grant, 2014). A recent British study of risk for COVID-19 hospitalization similarly found greater risk among those who were nondrinkers before virus exposure but only weak evidence for an increase in risk for those who were heavier drinkers (Hamer, Kivimakib, Gale, & Batty, 2020).…”

Section: Risky Behaviors and Disease Susceptibilitymentioning

confidence: 94%

Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19)

Cohen

2020

Perspect Psychol Sci

100

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For 35 years, our laboratory has been involved in identifying psychosocial factors that predict who becomes ill when they are exposed to a virus affecting the upper respiratory tract. To pursue this question, we used a unique viral-challenge design in which we assessed behavioral, social, and psychological factors in healthy adults. We subsequently exposed these adults to a cold or influenza virus and then monitored them in quarantine for 5 to 6 days for onset of respiratory illness. Factors we found to be associated with greater risk of respiratory illnesses after virus exposure included smoking, ingesting an inadequate level of vitamin C, and chronic psychological stress. Those associated with decreased risk included social integration, social support, physical activity, adequate and efficient sleep, and moderate alcohol intake. We cautiously suggest that our findings could have implications for identifying who becomes ill when exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). This argument is based on evidence that the associations we report are replicable across multiple respiratory viruses and that the pathways found to link psychosocial factors to colds and influenza may play similar roles in COVID-19.

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“…We have leveraged this model to define the impact of chronic drinking on circulating and tissue resident immune cells 41–46 . Specifically, using this model, we have shown that CMD enhances while CHD attenuates vaccine responses 42,44,47 . More recently, we reported significant transcriptional changes in PBMC from female rhesus macaque following 12 months of CHD using RNA-Seq and concluded that the circulating innate immune cells bear the largest burden of chronic heavy drinking 46 .…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effects of chronic alcohol drinking on peripheral immune responses

Sureshchandra

Raus

Jankeel

et al. 2019

Sci Rep

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It is well established that chronic heavy alcohol drinking (CHD) results in significant organ damage, increased susceptibility to infections, and poor outcomes following injury. In contrast, chronic moderate drinking (CMD) has been associated with improved cardiovascular health and immunity. These differential outcomes have been linked to alterations in both innate and adaptive branches of the immune system; however, the mechanisms remain poorly understood. To address this question, we determined the impact of chronic drinking on the transcriptional and functional responses of peripheral blood mononuclear cells (PBMC) collected from male rhesus macaques classified as CMD or CHD after 12 months of voluntary ethanol self-administration. Our analysis suggests that chronic alcohol drinking, regardless of dose alters resting transcriptomes of PBMC, with the largest impact seen in innate immune cells. These transcriptional changes are partially explained by alterations in microRNA profiles. Additionally, chronic alcohol drinking is associated with a dose dependent heightened inflammatory profiled at resting and following LPS stimulation. Moreover, we observed a dose-dependent shift in the kinetics of transcriptional responses to LPS. These findings may explain the dichotomy in clinical and immunological outcomes observed with moderate versus heavy alcohol drinking.

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Could moderate alcohol intake be recommended to improve vaccine responses?

Cited by 15 publications

References 18 publications

Demographic associations for autoantibodies in disease-free individuals of a European population

Demographic associations for autoantibodies in disease-free individuals of a European population

Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19)

Dose-dependent effects of chronic alcohol drinking on peripheral immune responses

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