Could Moesin Be a New Marker for Indicating Progression in Endometrial Cancer?

Ağaçayak, Elif; Keleş, Ayşenur; Deǧer, Uǧur; Ozcelik, Mehmet Sirin; Peker, Nurullah; Gündüz, Reyhan; Akkus, Murat; Büyükbayram, Hüseyin

doi:10.2147/cmar.s353225

Cited by 3 publications

(2 citation statements)

References 20 publications

(18 reference statements)

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“…Some studies have reported that MSN is abnormally expressed in some malignant tumor cells, and it plays an important role in the process of tumor invasion and metastasis 14 , 24 . MSN is an important potential target molecule of anti-tumor drugs 25 .…”

Section: Discussionmentioning

confidence: 99%

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

Zhuang¹,

Fan²,

Zhu³

et al. 2023

J. Cancer

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Background: Non-small cell lung cancer (NSCLC) is a common malignant tumor, and it is characterized by high mortality. and Moesin (MSN) have been proved to be related with regulation of tumors. If miR-452-5p could regulate NSCLC through targeting MSN remain unclear. Methods: TargetScan data and GEPIA databases were used to predict binding site and analyze gene expression, respectively. EdU staining, wound healing, and Transwell assays were performed to measure cell proliferation, migration, and invasion, respectively. Results: The binding site between miR-452-5p and MSN was predicted and validated. Overexpression of miR-452-5p cell lines were constructed, and miR-452-5p mimics markedly inhibited the migration, invasion, and proliferation ability of both H322 and A549 cells, but these effects of miR-452-5p were reversed by pcDNA-MSN. pcDNA-MSN significantly reversed the influence of miR-452-5p mimics on the EMT related proteins expression in H322 and A549 cell lines by decreasing E-cadherin and increasing N-cadherin. Significant higher expression of MSN in lung adenocarcinoma and lung squamous cell carcinoma was observed through GEPIA and TCGA data base analysis. Higher expression of MSN is positively correlated with advanced lung cancer and suggests poor prognosis. Conclusions: We demonstrated that miR-452-5p modulated the cell proliferation, migration, invasion, and EMT process of H322 and A549 cell lines through targeting MSN. This research might provide a novel prevention and treatment target for NSCLC.

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Section: Discussionmentioning

confidence: 99%

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

Zhuang¹,

Fan²,

Zhu³

et al. 2023

J. Cancer

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“…The molecular basis of this phenomenon is related to extragenomic modulation, in which estradiol and tamoxifen are involved. Furthermore, the activity of G proteins and Rho group-related kinases is modulated, directly affecting the migratory and proliferative properties of cells [ 23 , 24 ].…”

Section: Hormonal and Molecular Aspectsmentioning

confidence: 99%

Metastases and Recurrence Risk Factors in Endometrial Cancer—The Role of Selected Molecular Changes, Hormonal Factors, Diagnostic Methods and Surgery Procedures

Markowska,

Baranowski,

Pityński

et al. 2023

Cancers

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The presence of metastatic endometrial cancer (EC) is a key problem in treatment failure associated with reduced overall survival rates. The most common metastatic location is the pelvic lymph nodes, and the least common is the brain. The presence of metastasis depends on many factors, including the molecular profile of cancer (according to the TCGA—Genome Atlas), the activity of certain hormones (estrogen, prolactin), and pro-inflammatory adipocytokines. Additionally, an altered expression of microRNAs affecting the regulation of numerous genes is also related to the spread of cancer. This paper also discusses the value of imaging methods in detecting metastases; the primary role is attributed to the standard transvaginal USG with the tumor-free distance (uTFD) option. The influence of diagnostic and therapeutic methods on EC spread is also described. Hysteroscopy, according to the analysis discussed above, may increase the risk of metastases through a fluid medium, mainly performed in advanced stages of EC. According to another analysis, laparoscopic hysterectomy performed with particular attention to avoiding risky procedures (trocar flushing, tissue traumatization, preserving a margin of normal tissue) was not found to increase the risk of EC dissemination.

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Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma

Ito,

Kobori,

Urashima

et al. 2024

Journal of Reproductive Immunology

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Could Moesin Be a New Marker for Indicating Progression in Endometrial Cancer?

Cited by 3 publications

References 20 publications

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

Metastases and Recurrence Risk Factors in Endometrial Cancer—The Role of Selected Molecular Changes, Hormonal Factors, Diagnostic Methods and Surgery Procedures

Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma

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