Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

Fothergill‐Misbah, Natasha; Maroo, Harshvadan; Cham, Momodou; Pezzoli, Gianni; Walker, Richard; Cilia, Roberto

doi:10.1016/j.parkreldis.2020.03.002

Cited by 21 publications

(17 citation statements)

References 31 publications

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“…Its seed extracts exhibit potent neuroprotective activity due to the presence of L-DOPA in significant amount. This explains its popular use in the management of Parkinson disease [ 14 – 17 ]. Seeds extract of M. pruriens also possess antihyperglycemic, antihyperlipidemic and antitumor potentials in animal models [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Ogunmoyole

Ola-Awe

FATİLE

2021

BMC Complement Med Ther

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Background Mucuna pruriens (L.) has been used for the treatment of several ailments in folkloric medicine. The present study therefore investigates the hepatoprotective and nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver and kidney diseases. Methodology Forty male albino rats were randomly placed into eight groups comprising five animals each. Animals in group I were administered with the distilled water, while groups II and VI were exposed to CCl4 and rifampicin respectively. Animals in groups III and IV were initially exposed CCl4 and treated with 50 and 100 mg/kg bw M. pruriens respectively. Similarly, groups VII and VIII animals were exposed to rifampicin and treated with 50 and 100 mg/kg bw M. pruriens respectively. Animals in group V were treated with 100 mg/kg bw silymarin by oral gavage after an initial exposure to CCl4. Selected biomarkers of liver and kidney damage were determined in the serum and organs homogenate. Liver and kidney slices of experimental animals were also stained for histopathological examination. Results Exposure to CCl4 and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes and a surge in ALT, AST, ALP, urea, uric acid, bilirubin and creatine kinase. Treatment with M. pruriens extract reversed all deranged biochemical and histopathological parameters in a dose-dependent manner. Conclusion Extract of M. pruriens leaves restored deranged biochemical and histopathological parameters in the liver and kidney with similar potency to silymarin. Hence, leaf extract of M. pruriens is a potential hepatoprotective and nephroprotective agent that can be exploited in the management of liver and kidney diseases.

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Section: Introductionmentioning

confidence: 99%

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Ogunmoyole

Ola-Awe

FATİLE

2021

BMC Complement Med Ther

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“…7 The lack of availability of levodopa has encouraged researchers to investigate the use of locally sourced alternatives such as Mucuna pruriens. 23 Cubo et al 24 has also reported the limited availability and intermittent use of dopaminergic drugs and medications for non-motor symptoms in Cameroon. Similarly, a lack of availability of PD medications was reported in Kenya, where levodopa was available in only 24 (50%) pharmacies.…”

Section: Discussionmentioning

confidence: 99%

Availability of Therapies and Services for Parkinson's Disease in Africa: A Continent‐Wide Survey

et al. 2021

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“…Another area of ethnopharmacological interest in PD research in SSA and other low-income countries is the use of plant-based medicines for symptomatic PD treatment. Seeds of the leguminous plant Mucuna pruriens (velvet bean), which is found in many tropical regions including Africa, South America, and India, have been found to contain varying amounts of L-DOPA [138]. Some small trials have shown the non-inferiority of roasted Mucuna pruriens seeds to L-DOPA-carbidopa preparations for the relief of motor symptoms of PD, albeit with a slightly increased risk of gastrointestinal side effects [139][140][141].…”

Section: Challenges Of Parkinson's Disease Management In Low Resource Settingsmentioning

confidence: 99%

“…Larger placebo-controlled studies need to be conducted to determine effective dosages, tolerability, side effect profile, and to prove efficacy. A multicenter trial is currently ongoing in Ghana to answer some of these questions [138].…”

Section: Challenges Of Parkinson's Disease Management In Low Resource Settingsmentioning

confidence: 99%

Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa

Makanjuola¹,

Taiwo²,

Yaria³

et al. 2021

J Global Med

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Parkinson’s disease (PD) remains a common neurodegenerative movement disorder with significant morbidity, which is expected to increase worldwide in the coming decades. Since its initial description, much has been elucidated about its etiology, pathogenesis, and the role of genetic and environmental risk factors. Effective treatments, including surgical therapies, have been discovered. Despite these strides, many questions remain unanswered; PD remains an active research area with ongoing efforts to discover newer treatment modalities and identify neuroprotective strategies. As with many neurological conditions, there is an unequal distribution of health resources, resulting in some management challenges in low resource settings, especially sub-Saharan Africa (SSA). In this communication, we provide an overview of PD etiopathogenesis, including genetics and management strategies, including some recent advances with respect to treatment options and disease modification approaches. Finally, we discuss some challenges of PD management in low-resource settings and highlight efforts to turn the tide.

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Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

Cited by 21 publications

References 31 publications

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Availability of Therapies and Services for Parkinson's Disease in Africa: A Continent‐Wide Survey

Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa

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