2017
DOI: 10.1016/j.dsx.2016.06.024
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Could omega-3 fatty acids a therapeutic treatment of the immune-metabolic consequence of intermittent hypoxia in obstructive sleep apnea?

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Cited by 7 publications
(4 citation statements)
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“…In particular, evidence has been collected showing that n-3 PUFAs inhibit both the interleukin (IL)-1, 2, 6 synthesis and the protein kinase C signalling pathway [45]. This correlates with studies showing that n-3 PUFAs interfere in various ways in inflammatory processes, inhibiting IkB phosphorylation and therefore the NF-kB signaling pathway, or through PPARα/γ, or through a ligand for GPR120, which reduces both TLR-4 and tumour necrosis factor alpha (TNF-α) signalling pathway [42,43]. Moreover, n-3 PUFAs regulate leukotrienes, prostaglandins and thromboxanes synthesis, through activation of cytosolic phospholipase A 2 (cPLA 2 ), cyclooxygenase 2, and production of PGE 2 , as a cPLA 2 inhibitor, modify the metabolic pathway of arachidonic acid [17,18,46,47].…”
Section: Cell Membranes and Anti-inflammatory Effects Of N-3 Pufasmentioning
confidence: 63%
See 1 more Smart Citation
“…In particular, evidence has been collected showing that n-3 PUFAs inhibit both the interleukin (IL)-1, 2, 6 synthesis and the protein kinase C signalling pathway [45]. This correlates with studies showing that n-3 PUFAs interfere in various ways in inflammatory processes, inhibiting IkB phosphorylation and therefore the NF-kB signaling pathway, or through PPARα/γ, or through a ligand for GPR120, which reduces both TLR-4 and tumour necrosis factor alpha (TNF-α) signalling pathway [42,43]. Moreover, n-3 PUFAs regulate leukotrienes, prostaglandins and thromboxanes synthesis, through activation of cytosolic phospholipase A 2 (cPLA 2 ), cyclooxygenase 2, and production of PGE 2 , as a cPLA 2 inhibitor, modify the metabolic pathway of arachidonic acid [17,18,46,47].…”
Section: Cell Membranes and Anti-inflammatory Effects Of N-3 Pufasmentioning
confidence: 63%
“…In fact, linoleic acid and α-linolenic acid are fundamental constituents of cell membranes and are able to determine an impaired fluidity of membrane. Therefore, they determine and affect the behaviour of membrane-bound enzymes and receptors [42][43][44]. In particular, evidence has been collected showing that n-3 PUFAs inhibit both the interleukin (IL)-1, 2, 6 synthesis and the protein kinase C signalling pathway [45].…”
Section: Cell Membranes and Anti-inflammatory Effects Of N-3 Pufasmentioning
confidence: 99%
“…Other weight loss programs and diets have been unable to show any influence on sleep parameters [ 42 48 ] though there may be gender differences concerning success with weight loss and the effects of behavioral changes on bedtimes and nutrition [ 43 ].…”
Section: Resultsmentioning
confidence: 99%
“…Previous studies showed that PUFAs were associated with lower risks of CVDs ( 7 ), type 2 diabetes ( 8 ), and autoimmune disorders ( 9 ). PUFAs mainly include the plant-derived α-linolenic acid (ALA) and linoleic acid (LA), and seafood-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which were associated with lower immune response ( 10 , 11 ). Previous epidemiological studies showed that lower levels of circulating omega-3 PUFA were associated with a higher risk of SA ( 12 , 13 ), suggesting that diet-sourced omega-3 PUFAs may be modifiable targets for SA prevention.…”
Section: Introductionmentioning
confidence: 99%