Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?

Șurlin, Petra; Nicolae, Flavia Mirela; Şurlin, Valeriu; Pătrașcu, Ștefan; Ungureanu, Bogdan Silviu; Didilescu, Andreea Cristiana; Gheonea, Dan Ionuţ

doi:10.3390/jcm9123885

Cited by 15 publications

(11 citation statements)

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“…Additionally, Fusobacterium possesses adhesion and aggregation functions and can bind to most oral bacteria. 25 Fusobacterium can also adhere to some gut pathogenic bacteria, 26 which may disturb the gut microbiota, lead to intestinal inflammation, 27 , 28 and potentially serve as one of the biomarkers for detecting early intestinal bowel disease. 27 , 29 , 30 These results indicated that saliva-derived putative periodontopathic microbiota may enter the gut.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis may induce gut microbiota dysbiosis via salivary microbiota

Bao

Zhang

et al. 2022

Int J Oral Sci

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The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes. First, faecal and salivary samples were collected from periodontally healthy participants (PH group, n = 16) and patients with severe periodontitis (SP group, n = 21) and analysed by 16S ribosomal RNA sequencing. Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups. Notably, more saliva-sourced microbes were observed in the faecal samples of the SP group. Then, the remaining salivary microbes were transplanted into C57BL6/J mice (the C-PH group and the C-SP group), and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group, with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group. In the colon, the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression. The mRNA expression levels of pro-inflammatory cytokines, chemokines and tight junction proteins were significantly higher in the C-SP group. To further investigate whether salivary bacteria could persist in the intestine, the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice. We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h. Thus, our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.

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Section: Discussionmentioning

confidence: 99%

Periodontitis may induce gut microbiota dysbiosis via salivary microbiota

Bao

Zhang

et al. 2022

Int J Oral Sci

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“…Gingivitis is characterized by red, easily bled edematous gingiva and, if left untreated, the deeper periodontal tissues are implicated in the production of periodontitis that eventually ends in tooth loss [9]. Poor oral hygiene is created by local factors such as bacterial plaque and CALCULUS, which directly irritate periodontal tissues to cause periodontal diseases [10], [11]. Periodontal tissue is also directly affected by smoking and using tobacco products [5], [12], [15].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease Status in a Population at Najran Province of Saudi Arabia

Alshabab

Almakrami

Almilaq

et al. 2021

EJDENT

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Background: The common periodontal diseases are of public health concern, with 20-50 percent of the global population affected by gingivitis and or periodontitis. Aim: The aim of this study was to explore the common periodontal diseases occurring among the patients who attended the College of Dentistry hospital of Najran University. And also, to determine the correlation among the age groups, nationalities and risk factors related to periodontal diseases. Methods: A retrospective hospital-based descriptive type study was performed, providing 352 records of male patients suffering from various types of periodontal diseases. The Centers for Disease Control and the American Academy of Periodontology (CDC-AAP) classification was used for periodontal diagnosis. Patients were grouped by age as group A (6-20 years), group B (21-40 years), group C (41-60 years) and group D (above 60 years). Chi-square test and multinomial logistic regression model were adapted for data analyses. Results: Out of 352 patients, 217 (61%) and 135 (39%) patients suffered from gingivitis and periodontitis, respectively. Mean age of the patients was 32.81 ± 15.96 (range 6-97) years. Sixty-nine (19.6%), 200 (56.8%), 60 (17.0%) and 23 (6.5%) patients of Group A, B, C and D suffered from different forms of periodontal diseases, respectively. Eighty three percent patients were of Saudis and Yemenis and the rest were of Egyptian, Bangladeshi, Pakistani, Indian, Sudanese, Jordanian, Syrian, Chadian, Ghanaian and Tunisian nationalities. Highest number of patients suffered from moderate generalized gingivitis 142 (40.3%) and moderate localized periodontitis 57 (16.2%). Majority had plaque & calculus 290 (82.4%) and the rests had diabetes mellitus, smoking and tobacco chewing habit, asthma, hypertension and heart disease. Correlations among periodontal disease, age group and risk factor were found significant (p <0.05) though between the nationality and risk factor was found not significant (p 0.999). Conclusions: Significant relationships were observed among periodontal diseases and age, nationality and risk factors. This small study of Najran may reflect the periodontal status in a population of Saudi Arabia. Further broad scale study would be conclusive establishing such relationship in Saudi Arabian population.

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“…The mechanisms by which F. nucleatum accelerates tumor progression and metastasis and induces tumor-chemoresistance have been thoroughly reviewed previously. [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] This paper focuses on fusobacterial mechanisms that guide tumor-specific colonization and protect tumors against anti-tumor immunity.…”

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confidence: 99%