Could SARS‐CoV‐2 affect male fertility?

Vishvkarma, Rahul; Rajender, Singh

doi:10.1111/and.13712

Cited by 66 publications

(82 citation statements)

References 61 publications

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“…In addition to these structural effects of SARS‐CoV‐2 in the testis, many other studies also provide information that SARS viruses can cause orchitis in humans 5,25,30,31 . Because of the SARS virus and SARS‐CoV‐2 sharing 78% genetic homology and in the same family/genus, it would be correct to predict that SARS‐CoV‐2 will also have such an effect 25 .…”

Section: Sars‐cov‐2 In the Male Reproductive Systemmentioning

confidence: 99%

The other side of COVID‐19 pandemic: Effects on male fertility

Seymen

2020

Journal of Medical Virology

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The outbreak of novel coronavirus disease 2019 (COVID‐19) has become a major pandemic threat worldwide. According to the existing clinical data, this virus not only causes respiratory diseases and affects the lungs but also induces histopathological or functional changes in various organs like the testis and also the male genital tract. The renin‐angiotensin system (RAS), also ACE 2 and TMPRSS2 play an important role in the cellular entry for SARS‐CoV‐2. Because the male genital system presents high ACE 2 expression, the importance of this pathway increases in COVID‐19 cases. As the COVID‐19 pandemic has affected the male genital system in direct or indirect ways and showed a negative impact on male reproduction, this paper focuses on the possible mechanisms underlying the damage caused by COVID‐19 to the testis and also other components of the male genital tract.

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Section: Sars‐cov‐2 In the Male Reproductive Systemmentioning

confidence: 99%

The other side of COVID‐19 pandemic: Effects on male fertility

Seymen

2020

Journal of Medical Virology

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“…The SARS-CoV-2 virus uses angiotensin-converting enzyme 2 (ACE2) receptors to enter human cells, and the spike protein (protein S) is primed by transmembrane serine protease (TMPRSS2). The male reproductive system is believed to express both the ACE2 and TMPRSS2 receptor in the testes (spermatogonia, Sertoli and Leydig cells) and in prostate epithelial cells (for a review, see Hamdi et al, 2020;Vishvkarma R, & Rajender S, 2020). If receptors for the virus are present at different stages of the male reproductive system, it is not unreasonable to think that the virus could be found in semen either by alteration of the blood-testis barrier but also by excretion into prostatic fluid.…”

Section: Pre S En Ce or Abs En Ce Of Virus In S Emen?mentioning

confidence: 99%

COVID‐19 in men: With or without virus in semen, spermatogenesis may be impaired

et al. 2020

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We would like to congratulate you for the review recently published in Andrologia entitled 'Could SARS-CoV-2 affect male fertility?' (Vishvkarma R, & Rajender S, 2020). In just a few months, several million humans have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This brutal pandemic, called coronavirus-19 disease (COVID-19), disproportionately affects men and may have lasting impacts relating to aspects such as fertility. Some of these impacts are described in the literature, and others may be published in the coming months. Today, the literature focuses on whether the virus is present in semen, a possibility that is causing significant panic in the media and the public because the presence of the virus in the ejaculate would make COVID-19 an sexually transmitted infection (STI). However, beyond the answer to this question, there are symptoms of COVID-19 (e.g. fever) with the known andrological impacts that should be highlighted.

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“…Cells with high levels of ACE2 expression have the potential to be targeted and damaged by SARS-CoV-2. Single-cell transcriptome studies have revealed abundant ACE2 expression in Sertoli cells, Leydig cells, and spermatogonia, rendering all three categories of testicular cells potentially vulnerable to cellular damage by SARS-CoV-2 [2].…”

Section: Dear Editormentioning

confidence: 99%

“…TMPRSS2 (transmembrane protease serine 2) is utilized for S protein priming and is found in prostate epithelial cells [3,4]; androgen receptor activation is needed to trigger TMPRSS2 expression [1]. In addition, brain cells (neurons and glial cells) also express ACE2 receptors, raising the question of whether viral damage by SARS-CoV-2 may also disrupt the hypothalamic-pituitary-testicular axis and thereby disrupt normal male pubertal development and/or contribute to male infertility [2].…”

Section: Dear Editormentioning

confidence: 99%

“…There is some evidence correlating high ACE2 expression with infertility, suggesting that "an overactivation of ACE2 might affect spermatogenesis." [2] Of note, the highest number of ACE2-positive cells was found in a 30-year-old man (compared with a 20-year-old and 60-year-old man) [1]. As the COVID-19 pandemic evolves to strike younger populations of reproductive age globally, it remains an outstanding question whether there will be a rise in male factor infertility (or overall infertility) in general, as a result of this pandemic.…”

Section: Dear Editormentioning

confidence: 99%

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Mechanisms by Which SARS-CoV-2 May Impact Male Fertility

2020

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The COVID-19 pandemic is unlike anything we have experienced in over a century. In the USA, waves of COVID-19 have migrated from the Northeast to the Sun Belt to the Midwest over the past year. Compared with females, males are more susceptible to SARS-CoV-2 infection, have more severe COVID-19 disease, and have higher death rates. In many countries, men are consistently more likely to die by a factor of almost 2. This article describes some of the mechanisms by which COVID-19 may be associated with male infertility, as discussed by Dutta and Sengupta.

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Could SARS‐CoV‐2 affect male fertility?

Cited by 66 publications

References 61 publications

The other side of COVID‐19 pandemic: Effects on male fertility

The other side of COVID‐19 pandemic: Effects on male fertility

COVID‐19 in men: With or without virus in semen, spermatogenesis may be impaired

Mechanisms by Which SARS-CoV-2 May Impact Male Fertility

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