Could serum levels of irisin be used in gestational diabetes predicting?

Kulhan, Nur Gözde; Külhan, Mehmet; Turkler, Can; Kiremitli, Tunay; Kiremitli, Sevil

doi:10.1016/j.tjog.2019.01.027

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…A cross-sectional study by Kulhan et al also showed a lower serum concentration of irisin in pregnant women with GDM when compared with that of pregnant women without GDM. However, the authors additionally discovered that the maternal serum level of irisin has a negative correlation with BMI and a positive correlation with insulin resistance, and was negatively correlated with BMI but positively correlated with insulin resistance [142].…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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“…Kulhan et al evaluated the association between serum irisin levels and GDM. They also tried to estimate the possible benefits of the metabolic profile [ 127 ]. The results of the study showed that levels of serum irisin were lower in pregnant women with GDM compared to women with uncomplicated pregnancies [ 127 ].…”

Section: Biomoleculesmentioning

confidence: 99%

“…They also tried to estimate the possible benefits of the metabolic profile [ 127 ]. The results of the study showed that levels of serum irisin were lower in pregnant women with GDM compared to women with uncomplicated pregnancies [ 127 ]. In this cross-sectional study, the researchers noted that serum irisin levels in pregnant women were negatively correlated with BMI but positively correlated with insulin resistance.…”

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

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Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.

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“…Studies that assess the level of irisin in GDM are very heterogeneous in design, sample sizes, and results. Yuksel et al [ 17 ] also assessed the level of irisin in the umbilical cord blood sample, and they assessed the levels of irisin through the venous blood sample taken right before the delivery, whereas Kulhan et al [ 27 ] evaluated it with a single sample taken during the second trimester. On the other hand, Erol et al [ 20 ] took venous blood samples during the fi rst and second trimesters in their study, whereas Ebert et al [ 21 ] took the samples both antepartum and postpartum.…”

Section: Gdmmentioning

confidence: 99%

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Onat

2021

Z Geburtshilfe Neonatol

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Objective The objective of this study was to assess the levels of serum myonectin and irisin in pregnant women with and without gestational diabetes mellitus (GDM). Method A total of 80 pregnant women participated in our study (which consisted of 40 patients with GDM, 40 participants as the control group). Myonectin and irisin levels were analyzed through the ELISA technique, in addition to metabolic parameters in the serum samples of the participants. Results It was found that the levels of irisin and myonectin were lower in the GDM group compared to the control group. Moreover, it was determined that the values of age (p<0.001), body mass index (p=0.001), gravida (p=0.001), parity (p = 0.016), fasting serum glucose (p=0.001), fasting serum insulin (p=0.007), postprandial serum glucose (p=0.006), HbA1c (p<0.001), HOMA-IR (p<0.001) were higher; HDL cholesterol (p<0.001) was lower. Insulin resistance was significantly higher in the GDM group. Conclusions Levels of myonectin and irisin were determined to be low in the GDM group. Our results have demonstrated that myonectin and irisin could play a role in the development of GDM and that irisin as well as myonectin could be a novel biomarker for GDM.

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Could serum levels of irisin be used in gestational diabetes predicting?

Cited by 10 publications

References 13 publications

The Role of the Adipokines in the Most Common Gestational Complications

The Role of the Adipokines in the Most Common Gestational Complications

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

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