Could serum uric acid to HDL cholesterol ratio predict sacroiliitis?

Abstract

Recently, several inflammatory markers, including the uric acid to HDL cholesterol ratio (UHR), triglyceride/HDL cholesterol ratio (THR), systemic inflammatory index (SII), and C-reactive protein to albumin ratio (CAR), have been reported to be associated with inflammatory conditions. However, their collective role in sacroiliitis has not been extensively studied. This study aims to investigate the general characteristics and inflammatory markers in patients with and without sacroiliitis, and to observe any differences in these parameters in subjects with active and chronic sacroiliitis. Patient with sacroiliitis who showed up in the Radiology Department of Abant Izzet Baysal University Hospital were enrolled. Patients diagnosed with sacroiliitis based on clinical symptoms, physical examination, and conventional radiography or MRI findings were included in the sacroiliitis group. Patients without sacroiliitis who present with back pain or hip pain but have normal radiographic findings were included in the control group. General characteristics, including age, sex, body mass index (BMI), medical history, and disease duration, were collected from all participants. Blood samples were collected to measure inflammatory markers, including UHR, THR, SII, and CAR. The collected data were compared between sacroiliitis and control groups. Subgroup analysis was also performed to compare the inflammatory markers between subjects with active and chronic sacroiliitis. The median UHR of the sacroiliitis and control subjects were 11% (3–20%) and 7% (3–13%), respectively (p<0.001). Serum UHR was significantly and positively correlated with CRP (r: 0.4, p = 0.001) and ferritin (r: 0.17, p = 0.045) levels. In ROC analysis, a UHR level higher than 8% has an 81% sensitivity and 64% specificity in detecting sacroiliitis (AUC: 0.8, p<0.001, 95% CI: 0.72–0.84). In conclusion, we suggest that UHR could provide useful data as an additional diagnostic tool in patients with sacroiliitis.

The association between systemic inflammation markers and the prevalence of hypertension

“…As emerging biomarkers, the superiority of SII, SIRI and AISI have been identified in numerous diseases, including cancers, cardiovascular diseases, sacroiliitis and diabetic nephropathy [ 9 , 12 , 13 , 18 – 20 ]. Compared to traditional markers of inflammation, the three systemic inflammation markers are more favorable indicators of inflammatory status and have demonstrated superior predictive power and prognostic value in multiple studies [ 21 – 24 ].…”

Relationship between sacroiliitis and inflammatory markers in familial Mediterranean fever

“…Similarly, MLR is another inflammatory marker studied in malignancies 16 , gastrointestinal diseases 12 , and endocrine pathologies such as diabetes mellitus 17 , showing its significance. SII, which is another inflammation marker, has been investigated for its diagnostic value in various diseases, including sacroiliitis, and is a valuable indicator 18 , 19 . FMF is an autoinflammatory rheumatic disease, and sacroiliitis can be observed in FMF patients as it is associated with inflammation 20 .…”