Could the hypofrontality pattern in schizophrenia be modified through neuropsychological rehabilitation?

Penadés, Rafael; Boget, Teresa; Lomeña, Francisco; Mateos, J.J.; Catalán, Rosa; Gastó, Cristòbal; Salamero, Manel

doi:10.1034/j.1600-0447.2002.1o421.x

Cited by 70 publications

(24 citation statements)

References 41 publications

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“…Only a minority seem to be amenable to change by specific treatment interventions normally provided by psychiatrists. Better identification and treatment of depression and general psychopathology symptoms such as social anxiety and cognitive problems (Penades et al, 2002) might potentially improve subjective QOL in people with schizophrenia. Family contact was significantly associated with higher subjective QOL and better family support might improve family understanding and functioning and thus the amount of contact after the onset of psychosis.…”

Section: Discussionmentioning

confidence: 99%

Correlates of Subjective Quality of Life in People With Schizophrenia

Marwaha¹,

Johnson²,

Bebbington³

et al. 2008

Journal of Nervous &Amp; Mental Disease

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Quality of life (QOL) is an important outcome for people with schizophrenia, but most previous studies of its correlates have had small sample sizes or explored a limited number of variables. We conducted an analysis of the baseline data from the European Schizophrenia Cohort (EuroSC) study, a naturalistic investigation of people with schizophrenia living in France, Germany, and the United Kingdom (N = 1208). German participants had the highest subjective QOL. Country of residence, depression, accommodation status, and employment were the most important factors in explaining subjective QOL. Many correlates of subjective QOL in people with schizophrenia were similar to those in the general population. Many of the factors important in explaining subjective QOL in people with schizophrenia are not readily amenable to change. Differences in mental health service provision in the United Kingdom and Germany may in part explain variations in the QOL of people with schizophrenia resident there.

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Section: Discussionmentioning

confidence: 99%

Correlates of Subjective Quality of Life in People With Schizophrenia

Marwaha¹,

Johnson²,

Bebbington³

et al. 2008

Journal of Nervous &Amp; Mental Disease

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“…Still, while such exercises are often rooted in neuropsychology, the links between the exercises and change in neurobiological parameters are often not tested explicitly. Recently, Penades et al (2002) found improved performance on tasks known to assess prefrontal function as well as decreased hypofrontality on SPECT scanning following training on tasks that require prefrontal activity in individuals with schizophrenia. Such ''neurocognitive rehabilitation'' exercises have also been proposed and used for treatment of other conditions associated with prefrontal dysfunction such as addiction disorders (Allen, Goldstein, & Seaton, 1997;Cunha & Novaes, 2004).…”

Section: Cognitive Training Exercisesmentioning

confidence: 98%

Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression

2007

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The promise of a new generation of therapies targeted to address neurobiological mechanisms thought to underlie psychological disorders, particularly depression, using cognitive and behavioral techniques is discussed. Relationships between such neurobehaviorally focused therapies and other psychological and rehabilitative interventions are also discussed. Their potential utility as adjuncts to conventional treatment, and the importance of multi-method assessment in their evaluation are emphasized. Finally, initial data from a neurobehavioral ''cognitive control training'' (CCT) adjunctive intervention for severe unipolar depression is presented as an extended example. These data suggest that CCT aids in reducing both physiological mechanisms underlying depression as well as depressive symptomatology.

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“…In some patients a kind of "normalisation" of neuronal responses was assessed [82]. Altogether, the effects were small and inconsistent (see also [83]). Fig.…”

Section: Cognitive Rehabilitation Trainingmentioning

confidence: 99%

Functional Magnetic Resonance Imaging and Treatment Strategies in Schizophrenia

Karch

Pogarell²,

Mulert³

2012

CPB

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Neurobiological correlates of various treatment approaches (e.g. psychopharmacology, cognitive behavioural therapy) have become an important issue in recent neuroimaging studies. In schizophrenia, dysfunctions especially in frontal and parietal brain regions as well as the ventral striatum have been demonstrated in numerous studies. The review includes functional MRI studies about neurobiological correlates of treatment effects in schizophrenic patients. Treatment-associated changes in brain activity were shown especially in the anterior cingulate cortex, the dorsolateral prefrontal cortex, the ventral striatum and the amygdala. In addition, the differential effects of various treatment approaches including different neuroleptics (atypical neuroleptics, typical neuroleptics) as well as cognitive behavioural therapy will be considered in this review. The influence of functional differences on the differential effect of typical and atypical antipsychotics on cognitive functions will be discussed.

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Could the hypofrontality pattern in schizophrenia be modified through neuropsychological rehabilitation?

Abstract: Cognitive improvements after neuropsychological treatment would possibly be related with the diminution of the functional hypoactivity in the prefrontal areas.

Cited by 70 publications

References 41 publications

Correlates of Subjective Quality of Life in People With Schizophrenia

Correlates of Subjective Quality of Life in People With Schizophrenia

Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression

Functional Magnetic Resonance Imaging and Treatment Strategies in Schizophrenia

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