Could the infiltration of the thyroarytenoid muscle define the pT2 glottic carcinoma?

Lionello, Marco; Bertolin, Andy; Nardello, Ennio; Giacomelli, Luciano; Canal, Fabio; Rizzotto, Giuseppe; Marioni, Gino; Lucioni, Marco

doi:10.1002/hed.25893

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Hirano, almost 30 years ago, tried to investigate the depth of vocal muscle invasion to better understand the pathophysiological mechanism of vocal fold hypomobility, although he did not relate it with LC prognosis [ 28 ]. A recent study partly addressed this issue, demonstrating worse outcomes resulting from the histopathological finding of deep infiltration into vocal muscle in early LC, though not correlating the ensuing prognosis with a continuous linear measurement [ 29 ]. On the other hand, Yilmaz et al analyzed the role of deep neoplastic invasion in 74 laryngeal specimens, finding a direct correlation between this parameter and survival: in their work, the authors evaluated the correlation between depth of invasion (DOI) and nodal disease, showing that the mean DOI for N0, N1, N2, and N3 categories were 6.33, 8.72, 9.54, and 5.53 mm, respectively [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Marchi

Missale

Sampieri

et al. 2020

Cancers

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A picture is emerging in which advanced laryngeal cancers (LCs) are potentially not homogeneous and may be characterized by subpopulations which, if identified, could allow selection of patients amenable to organ preservation treatments in contrast to those to be treated with total laryngectomy (TL). This work aims to analyze a multicentric cohort of T3-T4a LCs treated by upfront TL, investigating the clinical and pathological features that can best predict oncologic outcomes. A total of 149 previously untreated patients who underwent TL for T3-T4a LC at four institutions were analyzed. Survival and disease-control were considered as the main outcomes. A secondary end-point was the identification of covariates associated with nodal status, investigating also the tumor thickness. T and N categories were significantly associated with both overall and disease-specific survival. The number of positive nodes and tracheal involvement were associated with loco-regional failure; post-cricoid area invasion and extra-nodal extension with distant failure. Posterior laryngeal compartment involvement was not a significant prognostic feature, by either univariable and multivariable analyses. These results support the conclusion that laryngeal compartmentalization has no impact on survival in patients treated by upfront TL and the current TNM staging system remains a robust prognosticator in advanced LC.

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Section: Discussionmentioning

confidence: 99%

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Marchi

Missale

Sampieri

et al. 2020

Cancers

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“…Muscle infiltration, pathological grade and microvascular invasion were listed as some of the most crucial factors for evaluating patient survival time and prognosis. The association between these variables and patient outcome is not strictly confined to bladder cancer, but also in other malignancies (32)(33)(34). Hence, STRN4 may serve a role as an independent prognostic factor.…”

Section: 0% CI For Hr -------------------------------mentioning

confidence: 99%

Altered expression of striatin‑4 is associated with poor prognosis in bladder transitional cell carcinoma

Zhang

Jiang

et al. 2021

Oncol Lett

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Striatin-4 (STRN4 or Zinedin) is a scaffolding protein belonging to the mammalian STRN family of proteins and consists of multiple functional signaling domains. Due to its numerous signaling complexes, STRN4 has been reported to be involved in the tumorigenesis of various cancer types, including colon cancer, liver cancer and prostate cancer. However, few studies on STRN4 have been conducted in bladder cancer, and its prognostic role in bladder cancer remains unknown. The present study aimed to investigate the expression levels of STRN4 in bladder transitional cell carcinoma and evaluate the prognostic role of STRN4. STRN4 expression in clinical specimens was analyzed using immunohistochemistry and reverse transcription-quantitative PCR. It was demonstrated that STRN4 expression was significantly associated with clinical parameters such as tumor size, muscle invasion depth and pathological tumor grade. Abnormal STRN4 expression was typically associated with worse overall survival time and outcome when compared with the low STRN4 expression group. Using multivariate analysis, it was reported that STRN4 was an independent prognostic biomarker for survival time in bladder transitional cell carcinoma. Although the specific biological mechanisms of STRN4 in bladder cancer still remain to be elucidated, STRN4 expression could be a prognostic indicator in bladder cancer.

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Transoral Approach for Early Laryngeal Cancers

Piazza

Eckel²,

Remacle³

et al. 2022

Textbook of Surgery of Larynx and Trachea

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Could the infiltration of the thyroarytenoid muscle define the pT2 glottic carcinoma?

Cited by 4 publications

References 19 publications

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Altered expression of striatin‑4 is associated with poor prognosis in bladder transitional cell carcinoma

Transoral Approach for Early Laryngeal Cancers

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