Could Vitamins Have a Positive Impact on the Treatment of Parkinson’s Disease?

Abstract

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease. Pathophysiologically, it is characterized by intracytoplasmic aggregates of α-synuclein protein in the Lewy body and loss of dopaminergic neurons from substantia nigra pars compacta and striatum regions of the brain. Although the exact mechanism of neurodegeneration is not fully elucidated, it has been reported that environmental toxins such as MPTP, rotenone, paraquat, and MPP+ induce oxidative stress, which is one of the causative factors for it. To date, there is no complete cure. However, the indispensable role of oxidative stress in mediating PD indicates that antioxidant therapy could be a possible therapeutic strategy against the disease. The deficiency of vitamins has been extensively co-related to PD. Dietary supplementation of vitamins with antioxidant, anti-inflammatory, anti-apoptotic, and free radical scavenging properties could be the potential neuroprotective therapeutic strategy. This review summarizes the studies that evaluated the role of vitamins (A, B, C, D, E, and K) in PD. It will guide future studies in understanding the potential therapeutic role of vitamins in disease pathophysiology and may provide a framework for designing treatment strategies against the disease.

Amyloidogenic and Neuroinflammatory Molecular Pathways Are Contrasted Using Menaquinone 4 (MK4) and Reduced Menaquinone 7 (MK7R) in Association with Increased DNA Methylation in SK-N-BE Neuroblastoma Cell Line

“…This is because vitamins commonly function as antioxidants or enzymatic cofactors [ 71 , 72 ]. A deficiency in, or a dysregulation of, specific vitamins adversely affects neuronal metabolism, which may lead to neurodegenerative diseases [ 73 , 74 , 75 , 76 ]. This prompted researchers to explore the role of different vitamins in the development and progression of diseases.…”

Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

“…It has a reliable antioxidant, anti-inflammatory 66, and antiapoptotic effects 67 . When it comes to the treatment and prevention of many diseases, vitamin D is a crucial therapeutic component 66,68 . Vitamin D3 receptors are expressed in bladder tissue 69 .…”

Food and Food Waste Antioxidants: Could They Be a Potent Defence against Parkinson’s Disease?

“…Moreover, thiamine supplementation may restore pathological changes and improve motor and non-motor symptoms associated with PD. Additionally, a thiamine decrease is correlated with a reduction in the α-ketoglutarate dehydrogenase complex, an enzyme associated with thiamine deficiency that could aggravate neurodegeneration in PD patients [ 63 ]. These findings are supported by Costantini et al, in a clinical study on PD patients.…”