Could γ/δ T cells influence the mother's rejection in recurrent aborted embryos?

Abstract

The possibility that the investigation of aborted material may identify aetiologies not easily detectable from even a careful clinical investigation, suggested a study of the T-cell receptors (TCRs) of decidual-infiltrating T-lymphocytes in recurrent spontaneous miscarriage (RSM). From 33 cases of RSM (>3 previous consecutive miscarriages, range 3-5, mean 3.7), PCR products were analysed by 15% acrylamide gel electrophoresis and visualised under UV illumination after ethidium bromide staining. A broad band obtained suggests the presence of a monoclonal T-lymphocyte proliferation. A PCR not showing bands means that the tissue does not contain reactive T cells. A total of 11 samples (33.3%) revealed the presence of receptor TCRgamma with the presence of a specific band. T-cell receptors in RSM were identified in one-third of cases. These data underline the importance of a maternal immune host response to the embryo and the need to study the immune mechanisms with the hope of modulating therapeutic treatment of recurrent abortion.

Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion

“…During LIT treatment, immunization with paternal lymphocytes stimulates the maternal immune system and motivates BA production that may contribute to a successful pregnancy. 16 In the present study, we observed that 77.9% of URSA patients became BA positive after LIT and the conversion rate increased along with more LIT. Accordingly, the pregnancy rate extensively ascended after LIT, from 29.6% to 65.3%, and live birth rate significantly grew, from 50.6% to 80.3%.…”