Coumarin end-capped poly(ε-caprolactone)-poly(ethylene glycol) tri-block copolymer: synthesis, characterization and light-response behavior

Sana, B.; Ferrentino, Nancy; Kohlan, Taha Behroozi; Lin, Min; Pašiškevičius, Valdas; Finne‐Wistrand, Anna; Pappalardo, Daniela

doi:10.1016/j.eurpolymj.2022.111760

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The synthesis of PCL-PEG block copolymers can be achieved by the ring-opening polymerization of ε-caprolactone (ε-CL) using PEG as initiator [10,15]. The molecular weight of the PCL block is primarily controlled by the molar ratio of ε-CL to the initiator PEG.…”

Section: Introductionmentioning

confidence: 99%

Poly(ε-caprolactone)-poly(ethylene glycol) Tri-Block Copolymer as Quercetin Delivery System for Human Colorectal Carcinoma Cells: Synthesis, Characterization and In Vitro Study

Ferrentino

Romano²,

Zappavigna

et al. 2023

Polymers

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Quercetin is a hydrophobic molecule with short blood circulation times and instability. The development of a nano-delivery system formulation of quercetin may increase its bioavailability, resulting in greater tumor suppressing effects. Triblock ABA type polycaprolactone-polyethylenglycol- polycaprolactone (PCL-PEG-PCL) copolymers have been synthetized using ring-opening polymerization of caprolactone from PEG diol. The copolymers were characterized by nuclear magnetic resonance (NMR), diffusion-ordered NMR spectroscopy (DOSY), and gel permeation chromatography (GPC). The triblock copolymers self-assembled in water forming micelles consisting of a core of biodegradable polycaprolactone (PCL) and a corona of polyethylenglycol (PEG). The core-shell PCL-PEG-PCL nanoparticles were able to incorporate quercetin into the core. They were characterized by dynamic light scattering (DLS) and NMR. The cellular uptake efficiency of human colorectal carcinoma cells was quantitatively determined by flow cytometry using nanoparticles loaded with Nile Red as hydrophobic model drug. The cytotoxic effect of quercetin-loaded nanoparticles was evaluated on HCT 116 cells, showing promising results.

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Section: Introductionmentioning

confidence: 99%

Poly(ε-caprolactone)-poly(ethylene glycol) Tri-Block Copolymer as Quercetin Delivery System for Human Colorectal Carcinoma Cells: Synthesis, Characterization and In Vitro Study

Ferrentino

Romano²,

Zappavigna

et al. 2023

Polymers

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Fluorescein Isothiocyanate Labelled PCL‐PEG‐PCL Copolymer as Delivery System of Capsaicin

Ferrentino,

Mariastella Caputo,

Cusano

et al. 2024

ChemNanoMat

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Amphiphilic block copolymers, made of biocompatible polycaprolactone (PCL) and polyethylene glycol (PEG), due to their ability to self‐assemble in water into nanoscopic micelles, have been largely exploited for drug delivery systems (DDS). This study introduces a novel approach by synthesizing a fluorescein isothiocyanate FITC‐labelled PCL‐PEG‐PCL triblock copolymer, with the aim to develop a drug delivery system for natural bioactive. As a proof of concept, the FITC‐labelled PCL‐PEG‐PCL copolymer is applied for the preparation of micelles encapsulating into the core capsaicin (CP), a pungent alkaloid found in chili peppers with diverse therapeutic applications. Challenges associated with CP's solubility, bioavailability, and stability are addressed using this DDS. Comprehensive characterization of FITC‐labelled copolymer is conducted using a range of analytical techniques, including nuclear magnetic resonance (NMR), dynamic light scattering (DLS), high‐performance liquid chromatography (HPLC), Fourier‐transform infrared spectroscopy (FTIR), fluorescence, and confocal laser scanning microscopy (CLSM). Key properties such as critical micelle concentration, CP loading, and release behavior are thoroughly investigated and compared with the characteristics of the unlabeled parent copolymer. This research pioneers the investigation of PCL‐PEG‐PCL triblock copolymers for CP delivery, along with the use of FITC‐labelled variants, opening new avenues for research in drug delivery and nanomedicine.

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Light and temperature dual stimuli-responsive micelles from carbamate-containing spiropyran-based amphiphilic block copolymers: Fabrication, responsiveness and controlled release behaviors

Zhang,

Min,

et al. 2023

European Polymer Journal

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Coumarin end-capped poly(ε-caprolactone)-poly(ethylene glycol) tri-block copolymer: synthesis, characterization and light-response behavior

Cited by 4 publications

References 41 publications

Poly(ε-caprolactone)-poly(ethylene glycol) Tri-Block Copolymer as Quercetin Delivery System for Human Colorectal Carcinoma Cells: Synthesis, Characterization and In Vitro Study

Poly(ε-caprolactone)-poly(ethylene glycol) Tri-Block Copolymer as Quercetin Delivery System for Human Colorectal Carcinoma Cells: Synthesis, Characterization and In Vitro Study

Fluorescein Isothiocyanate Labelled PCL‐PEG‐PCL Copolymer as Delivery System of Capsaicin

Light and temperature dual stimuli-responsive micelles from carbamate-containing spiropyran-based amphiphilic block copolymers: Fabrication, responsiveness and controlled release behaviors

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