Coumarin protects Cherax quadricarinatus (red claw crayfish) against white spot syndrome virus infection

Zhou, Xiujuan; Gong, Jing; Zhuang, Yongyong; Zhu, Faming

doi:10.1016/j.fsi.2022.06.005

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…In addition, the 7-(6-(2-methyl-imidazole))-coumarin reduced the viral titer of spring viremia of carp virus in zebrafish [40]. Feeding Cherax quadricarinatus, the Australian red claw crayfish, with low dose coumarin enhanced the cellular immunity of the animal and reduced the damage caused by white spot syndrome virus infection [41]. Addition of 7-hydroxycoumarin to the food of broiler chickens improved their health and growth in general and decreased their leucocyte cell counts significantly, which indicates that their state of immunity improved [42].…”

Section: Coumarins With Potential Immunity Enhancing Effectsmentioning

confidence: 99%

“…8-[(4-Chlorophenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One antimicrobial [34] pyrazole-coumarin hybrids antimicrobial [35] 4-bromopropoxycoumarin derivatives Antimicrobial, cytostatic [36] coumarin-piperazine hybrids Cytostatic [37] coumarin-N-heterocyclic hybrid Antimicrobial [38] 6-nitro-coumarin Fungicide [39] 7-(6-(2-methyl-imidazole))-coumarin Antiviral [40] Coumarin Antiviral [41] 7-hydroxycoumarin Enhanced immunity [42] 6-methoxy-7-hydroxy-coumarin Increased macrophage activity [43] 7-methoxy-8-[…”

Section: Compound Potential Activity Referencementioning

confidence: 99%

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Coumarins and their Derivatives as Potential Modulators of Immune Response

Bipat

2024

Adv Res Sci

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Coumarins are molecules varying from simple to more complex compounds that are widely available in nature, while some of them have been synthesized. They possess significant pharmacological potential, but until now their applicability in medicine has been limited to their ability to limit coagulation in blood. Our immune system plays a major role in disease states, with both ends of the spectrum being significant. Both a slow or absent immune reaction on one hand and an overreaction of the system on the other hand may be detrimental to our health. Since the process of coagulation seems to be related to the immune system, studies showing a possible role for coumarins and their lead compounds in modulating the immune system. were searched for in databases like PubMed, Google Scholar and Hinari. Several studies with promising results revealing a role for coumarins in modulating the immune response, were found However, all these studies have been carried out in in vitro and simple animal models. Randomized clinical trials will be required to demonstrate the therapeutic value of these readily available coumarin compounds.

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Section: Coumarins With Potential Immunity Enhancing Effectsmentioning

confidence: 99%