Coumarin Triazoles as Potential Antimicrobial Agents

Patil, Siddappa A.; Nesaragi, Aravind R.; Rodríguez-Berríos, Raúl R.; Hampton, Sydney M.; Bugarin, Alejandro; Patil, Shivaputra A.

doi:10.3390/antibiotics12010160

Cited by 14 publications

(5 citation statements)

References 55 publications

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“…Triazole derivatives have been well known for a long time and have recently gained increased interest from the scientific community due to their wide range of biological activities, such as anti-inflammatory, [11,12] anticancer, [13][14][15][16] anti-HIV, [17,18] antiviral, [19,20] antidiabetic, [21] analgesic, [12,22,23] antioxidant, [24,25] antitubercular, [23] anticoagulant, [23] antileishmanial, [24,25] antimalarial, [26,27] antimicrobial, [28][29][30][31][32][33] and others. [34] Furthermore, many approved drugs contain a 1,2,4-triazole ring in their structure, such as fluconazole, itraconazole, voriconazole, ravuconazole, and posaconazole, which are important antifungal agents (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

New 1H‐1,2,4‐Triazolyl Derivatives as Antimicrobial Agents

Sucman,

Stingaci,

Lupascu

et al. 2024

Chemistry & Biodiversity

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Thirteen new 1H‐1,2,4‐triazolyl derivatives were synthesized, and six of them were selected based on docking prediction for the investigation of their antimicrobial activity against five bacterial and eight fungal strains. All compounds demonstrated antibacterial activity with MIC lower than that of the ampicillin and chloramphenicol. In general, the most sensitive bacteria appeared to be P.fluorescens, while the plant pathogen X.campestris was the most resistant. The antifungal activity of the compounds was much better than the antibacterial activity. All compounds were more potent (6 to 45 times) than reference drugs ketoconazole and bifonazole with the best activity achieved by compound 4a A.versicolor, A.ochraceus, A.niger, and T.viride showed the highest sensitivity to compound 4b, while, T.viride,P. funiculosum, and P.ochrochloron showed good sensitivity to compound 4a. Molecular docking studies suggest that the probable mechanism of antibacterial activity involves the inhibition of the MurB enzyme of E.coli, while CYP51 of C. albicans appears to be involved in the mechanism of antifungal activity. It is worth mentioning that none of the tested compounds violated Lipinski's rule of five.

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Section: Introductionmentioning

confidence: 99%

New 1H‐1,2,4‐Triazolyl Derivatives as Antimicrobial Agents

Sucman,

Stingaci,

Lupascu

et al. 2024

Chemistry & Biodiversity

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“…Additionally, triazole compounds possess a diversity of biological activities as antimicrobial [35][36][37][38], antitubercular [39,40], potential inhibitors of SARS-CoV-2 [41][42][43], antiviral [43,44], anti-inflammatory [45,46],antitumor [47][48][49][50], antihypertensive [50], antioxidant [47,51,52], and antiepileptic [53,54]. Pharmacological applications of triazoles refer to their activity as α-glucosidase inhibitors [55,56], analgesics [50,57], anticonvulsants [53,58], and antimalarial agents [57,59].…”

Section: Introductionmentioning

confidence: 99%

Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review

Marinescu

2023

Antibiotics

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Bacterial infections have attracted the attention of researchers in recent decades, especially due to the special problems they have faced, such as their increasing diversity and resistance to antibiotic treatment. The emergence and development of the SARS-CoV-2 infection stimulated even more research to find new structures with antimicrobial and antiviral properties. Among the heterocyclic compounds with remarkable therapeutic properties, benzimidazoles, and triazoles stand out, possessing antimicrobial, antiviral, antitumor, anti-Alzheimer, anti-inflammatory, analgesic, antidiabetic, or anti-ulcer activities. In addition, the literature of the last decade reports benzimidazole-triazole hybrids with improved biological properties compared to the properties of simple mono-heterocyclic compounds. This review aims to provide an update on the synthesis methods of these hybrids, along with their antimicrobial and antiviral activities, as well as the structure–activity relationship reported in the literature. It was found that the presence of certain groups grafted onto the benzimidazole and/or triazole nuclei (-F, -Cl, -Br, -CF3, -NO2, -CN, -CHO, -OH, OCH3, COOCH3), as well as the presence of some heterocycles (pyridine, pyrimidine, thiazole, indole, isoxazole, thiadiazole, coumarin) increases the antimicrobial activity of benzimidazole-triazole hybrids. Also, the presence of the oxygen or sulfur atom in the bridge connecting the benzimidazole and triazole rings generally increases the antimicrobial activity of the hybrids. The literature mentions only benzimidazole-1,2,3-triazole hybrids with antiviral properties. Both for antimicrobial and antiviral hybrids, the presence of an additional triazole ring increases their biological activity, which is in agreement with the three-dimensional binding mode of compounds. This review summarizes the advances of benzimidazole triazole derivatives as potential antimicrobial and antiviral agents covering articles published from 2000 to 2023.

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“…The severity of the condition worsens when there is any kind of additional or major infection. All of this has made antimicrobials a very important and fundamental part of therapeutics and pharmacology [6,7].…”

Section: Introductionmentioning

confidence: 99%

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Kaur

Kaur²,

Alyami

et al. 2023

Antibiotics

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The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

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Coumarin Triazoles as Potential Antimicrobial Agents

Cited by 14 publications

References 55 publications

New 1H‐1,2,4‐Triazolyl Derivatives as Antimicrobial Agents

New 1H‐1,2,4‐Triazolyl Derivatives as Antimicrobial Agents

Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

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