Coumarins and a Naphthyl Labdanoate Diarabinoside from the Fruits of Peucedanum grande C. B. Clarke

Abstract

Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3α-ol-18-(3’’’-methoxy-2’’’- naphthyl-oate)-3α-L-arabinofuranosyl-(2’→1’’)-α-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicininduced nephrotoxicity in Wistar rats.

α-Glucosidase inhibitive diarylheptanoids from Ottelia acuminata var. acuminata, a traditional vegetable of Bai Nationality in Yunnan

“…By comparing spectroscopic data with literatures, the structures of 35 known compounds were elucidated as (1E,4E)-1,7-di(4-methoxyphenyl)-1,4-heptadiene (7) [15], tedarenes A (8) [16], trans-cinnamic acid (9) [17], p-hydroxymethylcinnamate (10) [18], trans-p-hydroxyl ethyl cinnamate (11) [19 3-(4-hydroxyphenyl)acrylic acid benzyl ester (12) [20], (2E)-3-(4-hydroxyphenyl)-2-propenoic acid 2-phenylethyl ester ( 13) [21] (E)-cinnamyl-(E)-p-coumarate ( 14) [22], (E)-cinnamyl-(Z)-p-Coumarate (15) [23], (E)-cinnamyl-(E)-ferulate ( 16) [23], bupleurumin (17) [24], marginatoxin (18) [25], 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl) butyrolactone (19) [26], Suchilactone (20) [27], osthol (21) [28], micropubescin (22) [29], 8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-2H-1-benzopyran-2-one (23) [29,30], murraol (24) [31] murrayacaurpin B (25) [32] 5,6-furanocoumarin ( 26) [33] xanthotoxin (27) [34], isopimpinellin (28) [35], sakuranetin (29) [36] 7,8-dihydroxyflavanone (30) [37], 5,3′-dihydroxy-7,4′dimethoxyflavanone (31) [38] pinostrobin (32) [39], tectochrysin (33) [40] 5,7-dihydroxy-flavone (34) …”