Coumarins and a Triterpenoid from Pithecellobium dulce

Katekhaye, Shankar; Laddha, K. S.

doi:10.1007/s10600-015-1460-z

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…) Benth.] ( Katekhaye and Laddha, 2015;Katekhaye et al, 2016). In the trunk bark of this species, two coumarins and two triterpenes were also identified (Katekhaye and Laddha, 2015;Katekhaye et al, 2016).…”

Section: Introductionmentioning

confidence: 77%

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Wood residues from Zygia racemosa (Ducke) Barneby & J.W. Grimes: Secondary metabolites, physical properties and anatomical aspects of the wood

Souza

Nascimento

Freitas

et al. 2022

Int J Innov Educ Res

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Zygia racemosa (Ducke) Barneby & J.W. Grimes (syn. Pithecellobium racemosum Ducke) is a large tree with its geographic distribution restricted to South America (Brazil, Colombia, Guyana, French Guiana, Peru and Suriname). It has a wide occurrence in the Brazilian Amazon and is abundant in campinarana and terra firme forest. In the present work, we evaluated the secondary metabolites, physical properties and anatomical aspects of wood residues of the species. The chromatographic fractionations of the hexane extract led to the isolation of steroids identified as spinastenone (1) and spinaterol (2). The methanol extract provided the steroids 1 and nonanoate-cholest-7, 22-dien-3β-ol (3), the triterpenes oleanolic acid (4) and 3β,21β-dihydroxyolean-12-en-28-oic acid (5). The basic density found was 0.81 g/cm3 and the anisotropic factor was 1.90, which confirms its excellent quality. The acquisition of a sample of wood residues from Zygia racemosa was an opportunity to generate knowledge regarding the secondary metabolism, the physical properties and the anatomical aspects of the wood of this species. The steroids and triterpenes identified suggest that they are associated with plant defense in Z. racemosa.

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Section: Introductionmentioning

confidence: 77%

“…( Katekhaye and Laddha, 2015;Katekhaye et al, 2016). In the trunk bark of this species, two coumarins and two triterpenes were also identified (Katekhaye and Laddha, 2015;Katekhaye et al, 2016). One sterolglycoside and two sterolglycolipids were found in the branches of Zygia cauliflora (Willd.)…”

Section: Introductionmentioning

confidence: 89%

Wood residues from Zygia racemosa (Ducke) Barneby & J.W. Grimes: Secondary metabolites, physical properties and anatomical aspects of the wood

Souza

Nascimento

Freitas

et al. 2022

Int J Innov Educ Res

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“…1) and have better solubility in non-polar solvents like chloroform, dichloromethane, etc. Bergapten was reported from chloroform extract of P. dulce bark [27] . Therefore, chloroform was selected as the extracting solvent to optimize the parameters affecting the MAE of bergapten in P. dulce.…”

Section: Resultsmentioning

confidence: 99%

“…The leaves are applied as plasters for pain and venereal sores [24] . P. dulce is reported to contain an important class of phyto constituent coumarins such as bergapten [27] , saponin glycosides like glycosides of oleanolic and echinocystic acids [28] , acylated triterpenoid saponin [29] , flavonoids apigenin [30,31] , triteepenoids, which includes lupeol, long chain aliphatic hydrocarbons such as lauric acid [32] and tannins [33] .…”

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confidence: 99%

Microwave-assisted Extraction and RP-HPLC Quantification of Bergapten from Pithecellobium dulce

Katekhaye¹,

Laddha²

2016

IJPS

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A comparative extraction efficiency study was performed for microwave assisted and other conventional extraction techniques. An accurate, precise and validated reverse phase high-performance liquid chromatography method was developed for estimation of bergapten from Pithecellobium dulce. Several parameters which can potentially affect the extraction yield, namely extraction technique, microwave power, extraction time and solid-liquid ratio were studied. The extraction conditions of microwave assisted extraction were optimized at extraction time of 10 min, microwave power of 700 W and solid-liquid ratio of 1:20 g/ml. The amount of bergapten in samples was analysed by reverse phase high-performance liquid chromatography using isocratic solvent system with chromatographic conditions of acetonitrile:water (65:35, v/v), RP column (4.6×250 mm, 5 μm), flow rate of 1.0 ml/min and UV wavelength of 266 nm. Under optimum conditions, linearity was obtained in the range of 0.5-10 µg/ml, with the correlation coefficient (R 2 ) above 0.996. Intraday (n=3) and interday (n=3) precisions for retention time and peak area were found to be less than 0.5 and 1.5%, respectively. The limit of detection and limit of quantification were 1.0 and 3.77 μg/ ml, respectively. The recovery expressed in relative standard deviation for the spiked compound at different concentrations (10, 20 and 30 µg/ml) was in the range of 0.95-1.09%. The developed microwave assisted extraction can be used as an alternative procedure to the conventional extraction techniques. The developed analytical method for estimation of bergapten has been demonstrated to be accurate, precise and reliable as per International Conference on Harmonisation guidelines.

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“…Numerous compounds have been identified in G. sepium [10][11][12][13][14], including Leucaena leucocephala (L. leucocephala) [15][16][17][18][19] and Pithecellobium dulce (P. dulce) [20][21][22][23]. However, the anthelmintic effect on H. contortus and the composition of the most active extract partitions of the species G. sepium, L. leucocephala, and P. dulce, which grow in a tropical dry forest (TDF) environment, are not known.…”

Section: Introductionmentioning

confidence: 99%

Ovicidal Effect on Haemonchus contortus of Extract Partitions Shrubby Plants of the Tropical Dry Forest and Potentially Active Compounds Identification by UHPLC-Q/Orbitrap/MS/MS

Romero-Jola,

Cubides-Cárdenas,

Escobar

et al. 2023

Applied Sciences

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The in vitro anthelmintic effect of the extracts on Haemonchus contortus (H. contortus) of three forage species in the tropical dry forest is known; however, there is no information about the effects of the extract partitions, nor their chemical composition. The objectives of this study were to evaluate the in vitro ovicidal activity of H. contortus in extract partitions of the species Gliricidia sepium, Leucaena leucocephala, and Pithecellobium dulce, and to identify the compounds present in the extract partitions with the highest activity by employing ultra HPLC Quadrupole orbitrap mass spectrometry. Four extract partitions, hexane, dichloromethane, ethyl acetate, and hydroethanolic from the three forage species were assessed in an inhibition of egg hatching (IEH) assay. The extract partitions with the highest anthelmintic activity (AA) were subjected to analysis, from which the tentative identification of the compounds was established. The extract partitions, including dichloromethane from Gliricidia sepium, ethyl acetate from Leucaena leucocephala, and hydroethanolic from Pithecellobium dulce showed a greater anthelmintic effect, with IC50 values of 0.39, 0.86, and 0.27 mg/mL for the IEH, respectively. Metabolites with in vitro AA potential included flavonoids, fatty acid esters, hydroxycinnamic acids, organic oxygenated compounds of the benzene class and substituted derivatives, phenolic glycosides, and phenols.

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Coumarins and a Triterpenoid from Pithecellobium dulce

Cited by 7 publications

References 10 publications

Wood residues from Zygia racemosa (Ducke) Barneby & J.W. Grimes: Secondary metabolites, physical properties and anatomical aspects of the wood

Wood residues from Zygia racemosa (Ducke) Barneby & J.W. Grimes: Secondary metabolites, physical properties and anatomical aspects of the wood

Microwave-assisted Extraction and RP-HPLC Quantification of Bergapten from Pithecellobium dulce

Ovicidal Effect on Haemonchus contortus of Extract Partitions Shrubby Plants of the Tropical Dry Forest and Potentially Active Compounds Identification by UHPLC-Q/Orbitrap/MS/MS

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