Coumarins and Phenols of Thapsia villosa Fruits

Méndez, J.; Rubido, J.

doi:10.1055/s-2008-1074858

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…[87][88] ( [44] Citrus spp., [46] Heracleum spp., [53][54] Murraya koenigii, [56] Stauranthus perforatus, [65] Byakangelicin (47) OMe OH OH O Amyris lineata, [89] Angelica spp., [44] Citrus spp., [46] Cymopterus watsonii, [67] Dorstenia gigas, [90] Magydaris pastinacea, [68] Murraya koenigii, [56] Peucedanum spp., [59] Ptelea trifoliata, [91] Ruta spp., [64] Thamnosma montana, [92] Thapsia villosa, [86] Triphasia trifolia, [24,74] Zanthoxylum pistacifolium [93] Neobyakangelicol (48) OMe OH O Angelica spp., [44] Citrus spp., [46] Murraya koenigii, [56] Peucedanum ostruthium [94] Japoangelone Angelica spp., [44] Citrus spp., [46] Dorstenia gigas, [90] Glehnia littoralis, [52] Niphogeton ternata [57] Notopterygium spp., [97][98] Petroselinum crispum, [99] Prangos spp., [62][63] Ruta spp., [64] Tordylium apulum [37] Cnidilin (53) O OMe Petroselinum crispum [99] Cnidicin (54)…”

Section: O Omentioning

confidence: 99%

Chemistry and Biological Activity of Natural and Synthetic Prenyloxycoumarins †

Curini¹,

Cravotto²,

Epifano³

et al. 2006

CMC

274

170

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Prenyloxycoumarins and prenyloxyfuranocoumarins (isopentenyloxy-, geranyloxy-, linear and cyclic sesquiterpenyloxy compounds and their biosynthetic derivatives) represent a family of secondary metabolites that have been considered for years just as intermediates of other coumarin-based compounds. Only in the last two decades these secondary metabolites have been recognized as interesting and valuable biologically active natural products. Up to now more than 160 compounds have been isolated from plants mainly belonging to the families of Rutaceae and Umbelliferae, comprising common edible vegetables and fruits like lemons, oranges and grapefruits. In view of the biological activity of some natural prenyloxycoumarins, very recently syntheses of structurally related analogs aimed to establish detailed structure-activity relationships have also been carried out. Many of the isolated prenyloxy- and prenyloxy-furanocoumarins and their semisynthetic derivatives were shown to exert in vitro and in vivo remarkable anti-tumoral, anti-inflammatory and anti-viral effects. The object of this review is to examine in detail the different types of prenyloxycoumarins and prenyloxyfuranocoumarins from the chemical, phytochemical and biological point of view.

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