Coumarins from African medicinal plants: A review of their cytotoxic potential towards drug sensitive and multidrug-resistant cancer cell lines

Nchiozem-Ngnitedem, Vaderament-A.; Dongmo, Appolinaire Kene; Tsamo, Leonel Donald Feugap; Kuete, Victor

doi:10.1016/bs.abr.2024.02.006

Advances in Botanical Research

2024

DOI: 10.1016/bs.abr.2024.02.006

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Coumarins from African medicinal plants: A review of their cytotoxic potential towards drug sensitive and multidrug-resistant cancer cell lines

Vaderament-A. Nchiozem-Ngnitedem,

Appolinaire Kene Dongmo,

Leonel Donald Feugap Tsamo

et al.

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2024

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Naturally‐occurring nematicides of plant origin: two decades of novel chemistries

Ibrahim,

Nchiozem‐Ngnitedem,

Dandurand

et al. 2024

Pest Management Science

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Plant‐parasitic nematodes are among the most destructive plant pathogens, resulting in a global annual economic loss of about 358 billion dollars. Using synthetic nematicides to control plant‐parasitic nematodes has resulted in broad‐spectrum toxicity to the environment. Plant‐derived secondary metabolites have recently emerged as viable options that provide effective, greener, and renewable routes for managing plant‐parasitic nematodes in various cropping systems. However, limited comprehensive information on plant‐derived secondary metabolites sources, chemical structures, and nematicidal activities is available. This study aims to compile and analyze data on plant‐based secondary metabolites with nematicidal properties collected over the last two decades. In this review, we identified 262 plant‐based metabolites with nematicidal activities that were isolated from 35 plant families and 65 plant species. Alkaloids, terpenoids, saponins, flavonoids, coumarins, thiophenes, and annonaceous acetogenins were among the most studied compounds. In addition to the structure–activity relation for specific metabolites with nematicidal potency, various techniques for their extraction and isolation from plant material are discussed. Our findings demonstrate the potential of plants as a feedstock for sourcing nematicidal compounds and discovering new chemistries that could potentially be used for developing the next generation of nematicides. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Naturally‐occurring nematicides of plant origin: two decades of novel chemistries

Ibrahim,

Nchiozem‐Ngnitedem,

Dandurand

et al. 2024

Pest Management Science

View full text Add to dashboard Cite

show abstract

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Coumarins from African medicinal plants: A review of their cytotoxic potential towards drug sensitive and multidrug-resistant cancer cell lines

Cited by 1 publication

References 100 publications

Naturally‐occurring nematicides of plant origin: two decades of novel chemistries

Naturally‐occurring nematicides of plant origin: two decades of novel chemistries

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