Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior

Kumar, Dinesh; Bhat, Zulfiqar Ali; Kumar, Vadlapudi; Shah, M. Y.

doi:10.1016/j.pnpbp.2012.08.004

Cited by 39 publications

(15 citation statements)

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“…Scopoletin shows MAO inhibition activity in a dose-dependent fashion, with IC 50 values of 19.4 μg/mL [19]. In addition, daphnoretin a bicoumarin of scopoletin and umbelliferone exhibits significant anxiolytic activity in EPM model [21-23]. It has been also suggested that coumarin derivatives interact with the benzodiazepine binding site of the GABA-A receptor [24].…”

Section: Discussionmentioning

confidence: 99%

Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice

et al. 2013

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BackgroundTraditional preparations of the root of Biebersteinia multifida DC (Geraniaceae), a native medicinal plant of Irano-Turanian floristic region, have been used for the treatment of phobias as anxiolytic herbal preparation.MethodsWe utilized the phobic behavior of mice in an elevated plus-maze as a model to evaluate the anxiolytic effect of the plant extract and bio-guided fractionation was applied to isolate the active compounds. Total root extract, alkaline and ether fraction were administered to mice at different doses 30 and 90 min prior to the maze test. Saline and diazepam were administered as negative and positive controls, respectively. The time spent in open and closed arms, an index of anxiety behavior and entry time, was measured as an index of animal activity.ResultsThe total root extract exhibited anxiolytic effect which was comparable to diazepam but with longer duration. This sustained effect of the crude extract was sustained for 90 min and was even more after injection of 45 mg/kg while the effect of diazepam had been reduced by 90 min. The anxiolytic effect factor was only present in the alkaline fraction and displayed its effect at lower doses than diazepam while pure vasicinone as the previously known alkaloid did not shown anxiolytic effect. The effect of the alkaline fraction was in a dose dependent manner starting at 0.2 mg/kg with a maximum at 1.0 mg/kg. Bio-guided fractionation using a variety of chromatographic methods led to isolation and purification of three coumarin derivatives from the bioactive fraction, including umbelliferone, scopoletin, and ferulic acid.ConclusionFor the first time, bio-guided fractionation of the root extract of B. multifida indicates significant sustained anxiolytic effects which led to isolation of three coumarin derivatives with well-known potent MAO inhibitory and anti-anxiety effects. These data contribute to evidence-based traditional use of B. multifida root for anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice

et al. 2013

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“…[212] The etiology of anxiety is not well known, but several studies revealed that dopaminergic and adrenergic systems and GABAergic and serotonergic neurotransmission are involved in the etiology, expression, and treatment of anxiety. [171819] Despite its widespread traditional use, there are no reports that scientifically provide the proof for the anxiolytic potential of C. pareira .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the latency time (time spent at the center of the maze), head dip count, rearing count and duration, and fecal bolus (stool bal) count were also recorded. [2131415]…”

Section: Methodsmentioning

confidence: 99%

“…Hand-operated counters and stop watches were used to score the behavior of animals, and experiments were performed with an observer inside the room. [241415]…”

Section: Methodsmentioning

confidence: 99%

“…[1] Globally, anxiety affects one-eighth of the population and has become an important research area for brain disorders and psychopharmacology. [2] Excessive anxiety can debilitate and damage the quality of healthy and wealthy life. Anxiolytic drugs are one of the most frequently prescribed drugs as the disease is highly prevalent in the society.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals

Thakur

Rana

2013

Journal of Traditional and Complementary Medicine

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The present study was undertaken to evaluate anxiolytic effect of 70% hydroethanolic extract of leaves of Cissampelos pareira in murine models. C. pareira (Menispermaceae) is rich in alkaloids, and phytochemical results showed that it contains alkaloids, flavanoids, terpenoids, steroids, etc., Anxiolytic activity was evaluated by using elevated plus maze test (EPM), light dark (LandD) model, and forced swim test (FS) models in rats. The efficacy of extract (100, 200, 400 mg/kg) was compared with control as well as standard diazepam (DZ; 2 mg/kg, p.o.) in EPM, LandD model, and imipramine (IM; 2.5 mg/kg, p.o.) in FS model. The results showed that DZ and extract significantly increased the number of entries, time spent in open arm, head dip counts, and rearing time, while they decreased fecal count in EPM. DZ and extract also significantly increased the number of crossings and time spent in light compartment, while they decreased duration of immobility in LandD model. In case of FS model, IM and extract significantly increased mobility and swimming time. Thus, the results confirm that hydroethanolic extract of C. pareira has the potential to be used in the management of anxiety-like behavior in a dose of 200 and 400 mg/kg. Further study is required to explore the plant and its parts for anxiolytic potential.

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Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway

Islam,

Malik,

Alshememry

et al. 2024

Drug Development Research

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Plant‐based components have helped generate novel lead molecules and scaffolds for anxiety research in psychopharmacology. The present study examined the anxiolytic properties of sesamol (SES), a phenolic lignan derived from Sesamum indicum, employing both in vivo and computational methods to understand its mechanisms of action. In this experiment, adult Swiss albino mice received various doses of SES (25 and 50 mg/kg, p.o.) orally. Afterward, a series of behavioral assessments, including open field, swing, hole cross, and light–dark testing, were conducted. The impact of the GABAergic agonist diazepam (DZP‐1 mg/kg, i.p.) along with the antagonist flumazenil (FLU‐0.1 mg/kg, i.p.) has been studied as provided concurrently with the SES‐50 group. Computational studies were performed to comprehend the interaction between SES and GABAA receptor subunits (α2 and α3). The results of our investigation revealed that SES dose‐dependently and significantly (p < 0.05) reduced the number of square crosses, hole crosses, swings, grooming, and rearing along with a reduction of light residence time in animals. When combined with DZP, SES‐50 significantly reduced all these parameters, while altering with FLU‐0.1. The molecular docking analysis showed that the SES has a relatively good binding score (−5.03 ± 0.15 and −5.25 ± 0.23 kcal/mol) with GABAA receptor α2 and α3 subunits, respectively. The SES triggers anxiolytic effects via GABAA receptor α2 and α3 subunit interactions. Furthermore, precise and comprehensive preclinical research must be considered to validate potential SES targets for anxiolytic impact, clinical trial efficacy, and safety.

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Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior

Cited by 39 publications

References 10 publications

Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice

Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice

Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals

Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway

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