Coumarins from the aerial parts of Prangos uloptera (Apiaceae)

Razavi, Seyed Mehdi; Nazemiyeh, Hossein; Hajiboland, R; Kumarasamy, Yashodharan; Delazar, Abbas; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.1590/s0102-695x2008000100002

Cited by 53 publications

(37 citation statements)

References 13 publications

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“…Previous phytochemical investigations on this plant revealed the presence of cloredan and neocloredan diterpenes in the aerial parts, and β-pinene and germacrene-D as the major components of the essential oils (Hernandez et al, 1980;Camps et al, 1984Camps et al, , 1987Boneva et al, 1990;Baser et al, 1999;Azizan et al, 2002;Velasco-Negueruela et al, 2004). In continuation of our phytochemical and pharmacological studies on the medicinal plants of the Iranian flora (Delazar et al, 2004(Delazar et al, , 2006(Delazar et al, , 2007(Delazar et al, , 2010a2011a,b;Babaei et al, 2008;Nazemieyh et al, 2008aNazemieyh et al, ,b, 2011Nazifi et al, 2008;Razvi et al, 2008Razvi et al, , 2011Modaressi et al, 2009;Asnaashari et al, 2010), we now report on the isolation, identification and free-radicalscavenging properties of three phenolic glycosides (1-3), and the composition of the essential oils of the aerial parts of Ajuga chamaepitys (L.) Schreb. growing in Iran.…”

Section: Introductionsupporting

confidence: 51%

Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran

Delazar

Delnavazi

Yassa

et al. 2012

Rev. bras. farmacogn.

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Abstract:From the methanolic extract of the aerial parts of Ajuga chamaepitys (L.) Schreb., Lamiaceae, one of the Iranian medicinal plants, the phenylethanoid glycoside, acteoside, and two flavone glycosides, chrysoeriol 7-Oglucopyranoside (3'-methoxy-luteolin 7-O-glucopyranoside) and apigenin 7-Orhamnopyranoside, were isolated by a combination of solid-phase extraction (SPE) and preparative reversed-phase high-performance liquid chromatography (prep-RP-HPLC) methods. Structures of the isolated compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of the extracts, fractions and isolated compounds were determined by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. While among the extracts, the MeOH extract showed the highest level of free-radical-scavenging activity (RC50 1.15 × 10 -¹ mg/mL), chrysoeriol 7-O-glucopyranoside was the most active (RC50 3.00 × 10 -³ mg/mL) among the isolated compounds. The GC-MS and the GC-FID analyses revealed α-pinene (23.66%), β-pinene (9.33%), 1-octen-3-ol (9.72%), β-phellandrene (8.70%) and germacrene-D (7.92%) as the major components of the essential oils derived from the aerial parts of this plant. The presence of phenolic glycosides and the α-and β-pinene-rich essential oils in A. chamaepitys may provide some rationale for the traditional medicinal uses of this species in Iran.

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Section: Introductionsupporting

confidence: 51%

Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran

Delazar

Delnavazi

Yassa

et al. 2012

Rev. bras. farmacogn.

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“…Esses compostos derivados de plantas medicinais com atividades antioxidantes tem sido isolado das mais diversas famílias de plantas (Boudet, 2007, Razavi et al, 2008 e os flavonóides são, por certo, as substâncias representativas desta atividade (Van Den Berg et al, 2000), uma vez que possuem esqueleto carbônico propício para a estabilização de radicais livres. Contudo, a intensidade da ação antioxidante exibida por estes fitoquímicos é diferenciada, principalmente devido ao número e posição de hidroxilas presentes nas moléculas (Melo et al, 2008).…”

Section: Resultsunclassified

Metabólitos Secundários e ação antioxidante de Croton helliotripifolius e Croton blanchetianus

et al. 2017

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ResumoAntioxidantes são compostos que reagem com os radicais livres controlando o estresse oxidativo. Muitas doenças estão associadas à produção de radicais livres, os quais tem estimulado investigações do potencial antioxidante de diversas famílias da flora mundial. Essa pesquisa teve como objetivo identificar as principais classes de metabólitos secundários presentes nos estratos etanólicos das folhas de Croton blanchetianus (Marmeleiro) e Croton heliotropiifolius (Velame), e avaliar o seu potencial antioxidante. Os estratos etanólicos foram obtidos das folhas, apresentou um rendimento de 3,29% e 3,26%. Em seguida, os estratos foram submetidos a análise fitoquímica, nos quais foi possível identificar a presença de taninos condensados, flavonoides, flavononas, flavonóis, flavononóis, catequinas e xantonas. A atividade antioxidante dos estratos foi determinada pelo método fotocolorimétrico in vitro realizada por meio do sequestro de radicais livres, usando o DPPH (1,1-difenil-2-picrilhidraliza). Ambos os estratos foram capazes de sequestrar o radical livre DPPH, sendo que o estrato de Croton blanquetianus mostrou ser mais eficiente do que o BHT (Hidroxitolueno butilado; controle positivo), com CE50 = 6,5 ± 0,5 mg mL -1 . Contudo, os resultados observados para os estratos etanólicos, possivelmente sejam atribuídas à presença e a concentração de compostos fenólicos pertencentes as classes dos taninos e flavonoides, os quais foram identificados nesse estudo. Palavras-chave: Radicais livres, fitoquímica, fotocolorimétrico Secondary metabolites and antioxidant action of Croton heliotropiifolius andCroton blanchetianus Abstract Antioxidants are compounds that, at optimal concentrations in relation to oxidable substrates, react with free radicals preventing or reducing oxidative stress. Many diseases and degenerative processes are associated with overproduction of free radicals. This stimulated several research groups to investigate the antioxidant potential of substances produced by several families of the world flora. This study identified the major classes of secondary metabolites present in ethanol leaf extracts of C. blanchetianus (Marmeleiro) and C. heliotropiifolius (Velame), and assessed their antioxidant potential. Ethanol extracts were obtained by the exhaustive extraction method cold and resulted in 3.29% and 3.26% extraction efficiency. Then phytochemical analyses were performed on the extracts to investigate the presence of tannins, flavonoids, flavonones, flavonols, catechins and xanthones. The antioxidant activity of extracts was determined by in vitro photocolorimetric method based on the sequestration of free radicals, using DPPH (1,1-diphenyl-2-picryl-hydrazyl). Both extracts were able to sequestrate DPPH free radical. Croton blanchetianus extract activity showed to be more efficient than BHT (Butylated Hidroxytoluene) (positive control), with EC50 = 6.5 ± 0.5 mg mL -1 . Croton heliotropiifolius extracts showed lower antioxidant activity, with EC50 = 50.15 ± 0.21 but still higher than that observed fo...

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“…A família Apiaceae é conhecida por apresentar alguns óleos essenciais (Dethier, 1941) na folha como limoneno e linalol (Hadaruga et al, 2005); monoterpenos e cumarinas (Ribeiro & Kaplan, 2002;Razavi et al, 2008). As cumarinas estão presentes em diferentes partes das plantas tanto nas raízes como nas fl ores e frutos e podem estar distribuídas em diferentes famílias de Angiospermas como Apiaceae, Rutaceae, Asteraceae nas quais são encontradas com ampla ocorrência (Ribeiro & Kaplan, 2002;Taleb-Contini et al, 2006).…”

Section: Introductionunclassified

Caracterização anatômica e química da folha e do sistema radicular de Hydrocotyle umbellata (Apiaceae)

Martins¹,

Marconi²,

Cavalheiro³

et al. 2008

Rev. bras. farmacogn.

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Coumarins from the aerial parts of Prangos uloptera (Apiaceae)

Cited by 53 publications

References 13 publications

Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran

Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran

Metabólitos Secundários e ação antioxidante de Croton helliotripifolius e Croton blanchetianus

Caracterização anatômica e química da folha e do sistema radicular de Hydrocotyle umbellata (Apiaceae)

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