Background. Epithelial salivary gland neoplasms are rare in children. Malignant tumors account for 30% to 50% of cases in the pediatric age group, with mucoepidermoid carcinoma as the most common histology.Methods. A retrospective medical record review was conducted from 1953 to 2007 to identify patients with mucoepidermoid carcinoma at the age of 18 years or younger at the time of diagnosis. Forty-nine patients were identified. Their medical records were examined for presentation, treatment, pathologic features, and outcomes.Results. Forty-nine pediatric patients with mucoepidermoid carcinoma were identified. The parotid gland (49%) and oral cavity (35%) were the most common subsites. Nodal metastasis was seen in 24% of patients. All patients underwent surgery, and 11 patients (22%) were treated with radiation therapy. The 5-year overall survival was 98%, the 10-year overall survival was 94%, and 10% of patients developed recurrence.Conclusion. Mucoepidermoid carcinoma in children carries a favorable prognosis and can be successfully treated with surgery alone in most cases. V V C 2011 Wiley Periodicals, Inc.* Head Neck 33: 1769-1773, 2011Keywords: mucoepidermoid carcinoma; salivary gland; children; malignancy; surgery Salivary gland tumors are rare in both adults and children, accounting for less than 3% of head and neck tumors. Less than 5% of these tumors occur in the pediatric population.1,2 Malignant tumors account for 30% to 50% of cases in the pediatric age group, with mucoepidermoid carcinoma being the most common histology.1,3,4 These tumors not only occur in the major salivary glands, but also are commonly found in the oral cavity. Historically, patients have been treated primarily with surgical excision. Radiation therapy has traditionally been reserved for highgrade histology, positive margins, and lymph node involvement.
3-8However, these therapeutic approaches are based upon small reported series from diverse groups, or extrapolated from the biological behavior of adult mucoepidermoid carcinoma. Furthermore, the impact of tumor grade, which is of demonstrable importance in adults, has not been adequately studied in pediatric patients. Cohesive treatment strategies are thus wanting. Therefore, we reviewed our institutional experience to determine the presentation, pathologic features, treatment, and outcomes for pediatric mucoepidermoid carcinomas.
MATERIALS AND METHODSAfter institutional review board approval was obtained, the medical records of all patients with a diagnosis of mucoepidermoid carcinoma of the salivary glands who were 18 years old and younger were reviewed. Medical records were examined for clinical presentation, treatment, pathologic features, and outcome. Clinical information gathered included: sex, age at diagnosis, ethnicity, tumor site, TNM classification according to the American Joint Committee on Cancer criteria, histologic features, treatment course, and outcomes. For statistical purposes, comparisons of categorical data were made using the chi-square with the Fis...